Admixture-mediated adaptation to malaria in a human population demonstrates that detectible signatures in genomic patterns of ancestry can be leveraged to better characterize recent selection in populations with mixed ancestry.
A novel role of endosomal machineries retromer and ESCRT in membrane delivery of Drosophila septate junction components is required for maintenance of junction integrity and epithelial barrier function.
Muscle fiber growth during development is controlled by the Hippo pathway that links the assembly state of the contractile sarcomeres with the transcriptional state of the sarcomeric genes.
Theoretical study shows how enzymes can achieve substrate proofreading by taking advantage of existing molecular gradients in the cell while not being endowed with structural features typically required for proofreading.
The molecular identity of bi-fated tendon-to-bone attachment cells, which display a mixture of transcriptomes of two neighboring cell types, enables the formation of the unique transitional tissue of the enthesis.
Single-cell RNA-sequencing identifies the precise cellular and molecular events that occur along the sepsis timeline in the kidney, pointing to potential biomarkers and therapeutic targets.