In contrast to published findings showing exclusion, transcription factors in fact bind mitotic chromosomes in a dynamic fashion, allowing for efficient transmission of transcription programs through mitosis.
Binding of multiple LC8 copies to the intrinsically disordered region of the transcription factor ASCIZ exemplifies a new and potentially widespread molecular mechanism for negative feedback regulation.
Experimental mapping of the joint sequence space of an ancient transcription factor (TF) and its DNA binding sites reveals that epistasis across the molecular interface permitted the evolution of a new and specific TF-DNA complex.
Bacteria use the transcription factor binding region of their transcription activator-like effectors to hijack host basal transcription factor to cause rice diseases by activating host susceptibility genes.
The collective action of six transcription factors selects and activates the regulatory regions of the HSN serotonergic neuron effector genes constituting a signature that can be used for the novo identification of HSN expressed genes.