A member of the Drosophila Nuclear Export Factor (Nxf) family, Nxf2, forms part of the piRNA-dependent co-transcriptional silencing complex and is essential for transposon repression in fly ovaries.
Spatial factors generate neuroblast-specific open chromatin, thereby biasing the subsequent binding of transcription factors to produce neuroblast-specific neurons.
In contrast to published findings showing exclusion, transcription factors in fact bind mitotic chromosomes in a dynamic fashion, allowing for efficient transmission of transcription programs through mitosis.
A comprehensive study of human transcription factors reveals that a greater number of these proteins bind to methylated DNA sequences than previously thought.
Binding of multiple LC8 copies to the intrinsically disordered region of the transcription factor ASCIZ exemplifies a new and potentially widespread molecular mechanism for negative feedback regulation.
Single molecule DNA unzipping reveals a novel model for the regulation of transcription factors and nucleosome positioning via nucleosome remodeling in yeast.
Experimental mapping of the joint sequence space of an ancient transcription factor (TF) and its DNA binding sites reveals that epistasis across the molecular interface permitted the evolution of a new and specific TF-DNA complex.
The collective action of six transcription factors selects and activates the regulatory regions of the HSN serotonergic neuron effector genes constituting a signature that can be used for the novo identification of HSN expressed genes.
Bacteria use the transcription factor binding region of their transcription activator-like effectors to hijack host basal transcription factor to cause rice diseases by activating host susceptibility genes.
