244 results found
    1. Genes and Chromosomes
    2. Immunology and Inflammation

    Gene-specific mechanisms direct glucocorticoid-receptor-driven repression of inflammatory response genes in macrophages

    Maria A Sacta et al.
    A comprehensive analysis of the glucocorticoid-sensitive pro-inflammatory genes in macrophages reveals fundamental differences between the temporal events and components of transcriptional machinery that the glucocorticoid receptor targets to repress their transcription.
    1. Genes and Chromosomes

    HIV: The two sides of Tat

    Matjaz Barboric, Koh Fujinaga
    Available as:
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    1. Developmental Biology and Stem Cells
    2. Genes and Chromosomes

    Science Forum: Considerations when investigating lncRNA function in vivo

    Andrew R Bassett et al.
    We discuss the methods available to understand lncRNA function in vivo, and highlight important considerations that should be taken into account when designing such experiments.
    1. Neuroscience

    Orphan receptor GPR158 controls stress-induced depression

    Laurie P Sutton et al.
    The orphan receptor GPR158 is highly regulated by stress exposure and acts on key neuronal signaling pathways in the prefrontal cortex to control depressive-like behaviors.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response

    Carmela Sidrauski et al.
    A drug-like molecule called ISRIB, which activates the translation initiation factor eIF2B, antagonizes stress responses as diverse as protein misfolding and nutrient deprivation, and restores protein synthesis, enhancing memory.
    1. Developmental Biology and Stem Cells
    2. Plant Biology

    Control of plant cell fate transitions by transcriptional and hormonal signals

    Christophe Gaillochet et al.
    HEC transcription factors control the timing of cell fate transitions in a dynamic stem cell system, allowing plants to adapt their developmental program to diverse environments.
    1. Developmental Biology and Stem Cells

    Live imaging of heart tube development in mouse reveals alternating phases of cardiac differentiation and morphogenesis

    Kenzo Ivanovitch et al.
    Tissue-level coordination of cardiac progenitor cells in the early mouse embryo produces a temporal compartmentalization of differentiation and morphogenesis essential for heart tube formation.
    1. Developmental Biology and Stem Cells
    2. Human Biology and Medicine

    Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids

    Marko Z Nikolić et al.
    Improved characterisation of human embryonic lung development highlights human-mouse differences and facilitates the development of defined culture conditions for the expansion of self-renewing, multipotent human lung epithelial progenitor cells.
    1. Developmental Biology and Stem Cells
    2. Genomics and Evolutionary Biology

    In vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse

    Marco Morselli et al.
    DNA methylation deposition is dependent on the presence of H3K4me3 and H3K36me3 histone marks.
    1. Developmental Biology and Stem Cells
    2. Genes and Chromosomes

    ME31B globally represses maternal mRNAs by two distinct mechanisms during the Drosophila maternal-to-zygotic transition

    Miranda Wang et al.
    ME31B is a general repressor of gene expression in the Drosophila early embryo, repressing translation before the maternal-to-zygotic transition and stimulating mRNA decay after activation of the zygotic genome.

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