1,222 results found
    1. Cell Biology

    The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis

    Philipp Kimmig et al.
    A unique form of regulation has been observed in the unfolded protein response of S. pombe, along with a novel mechanism of post-transcriptional mRNA processing.
    1. Chromosomes and Gene Expression

    Non-canonical TAF complexes regulate active promoters in human embryonic stem cells

    Glenn A Maston et al.
    The transcription machinery used to regulate gene expression and self-renewal in human embryonic stem cells is different from that found in other cells.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands

    Anca M Farcas et al.
    A protein that can recognize regions of DNA with a high proportion of unmethylated CpG dinucleotides, and then recruit polycomb group proteins to these CpG islands, has been identified.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    DNA-PK is a DNA sensor for IRF-3-dependent innate immunity

    Brian J Ferguson et al.
    Experiments in mice have shown than an enzyme that repairs broken DNA inside the nucleus also has a central role in the innate immune system because it is able to detect foreign DNA outside the nucleus.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure

    Taesun Eom et al.
    The HITS-CLIP sequencing method is used to demonstrate that cryptic exons can detect messenger RNA that contains nonsense mutations, and then cause this RNA to decay, which shows that these exons are involved in maintaining the electrical balance of neurons and, possibly, preventing epilepsy.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome

    Rati Verma et al.
    The enzyme that collaborates with ubiquitin ligases to promote the release of defective polypeptides from stalled ribosomes in a process named ribosome-associated degradations has been identified as the ATPase Cdc48.
    1. Genetics and Genomics

    RNA-programmed genome editing in human cells

    Martin Jinek et al.
    A bacterial protein can be programmed with short RNA molecules to stimulate genome editing at specific sites in human cells.
    1. Cell Biology

    Time line of redox events in aging postmitotic cells

    Nicolas Brandes et al.
    A sudden fall in the levels of the coenzyme NADPH within cells could have a central role in the process of aging.
    1. Cell Biology
    2. Developmental Biology

    Mitotic spindle scaling during Xenopus development by kif2a and importin α

    Jeremy D Wilbur, Rebecca Heald
    An interaction between two proteins enables the spindle—the structure that segregates chromosome pairs during mitosis—to change size as cells divide.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates

    Hannah K Long et al.
    Islands of non-methylated DNA are shown to perform a similar epigenetic role in many different vertebrate species.

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