4,074 results found
    1. Cell Biology
    2. Developmental Biology

    The transcription factor Rreb1 regulates epithelial architecture, invasiveness, and vasculogenesis in early mouse embryos

    Sophie M Morgani et al.
    Loss of the transcription factor Rreb1 results perturbs epithelial architecture during mouse development resulting in invasive cell behaviors, severe cardiovascular defects, and embryonic lethality.
    1. Genetics and Genomics
    2. Neuroscience

    Integrated transcriptomic and neuroimaging brain model decodes biological mechanisms in aging and Alzheimer’s disease

    Quadri Adewale et al.
    Identification of causal genes and their effects on other biological determinants untangles the complexities of aging and Alzheimer's and can facilitate drug discovery for sustaining healthy aging and treating Alzheimer's.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist

    Caleb R Glassman et al.
    A panel of interleukin-2 partial agonists designed to exploit distinct immune cell response thresholds enabled selective activation of regulatory T cells in vivo.
    1. Genetics and Genomics

    PIE-1 SUMOylation promotes germline fates and piRNA-dependent silencing in C. elegans

    Heesun Kim et al.
    PIE-1 engages SUMO to preserve the embryonic germline fate and also to promote the assembly of a MEP-1/Mi-2/HDA-1 chromatin remodeling complex required for inherited Argonaute-mediated gene silencing in the adult hermaphrodite germline.
    1. Developmental Biology

    Competitive coordination of the dual roles of the Hedgehog co-receptor in homophilic adhesion and signal reception

    Shu Yang et al.
    The apparently incompatible functions of the Hedgehog co-receptor Ihog in homophilic adhesion and ligand binding cooperate in Hh transport and reception.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Psychomotor impairments and therapeutic implications revealed by a mutation associated with infantile Parkinsonism-Dystonia

    Jenny I Aguilar et al.
    A dopamine transporter deficiency syndrome (DTDS)-linked mutation, R445C, underlies dopamine dysfunction and, more broadly, the clinical phenotypes shared by DTDS and Parkinson’s disease.
    1. Developmental Biology

    HDAC1 SUMOylation promotes Argonaute-directed transcriptional silencing in C. elegans

    Heesun Kim et al.
    HDAC SUMOylation promotes the association of other chromatin remodeling factors with the nuclear Argonaute WAGO-9, which is required for de novo heterochromatin silencing.
    1. Cancer Biology

    Limited inhibition of multiple nodes in a driver network blocks metastasis

    Ali Ekrem Yesilkanal et al.
    Low-dose treatment targeting multiple pathways of a pro-metastatic signaling network reduces the metastatic output of heterogeneous tumors while minimizing compensatory network activation.
    1. Biochemistry and Chemical Biology

    OPA1 deletion in brown adipose tissue improves thermoregulation and systemic metabolism via FGF21

    Renata O Pereira et al.
    Lack of OPA1 in BAT impairs its thermogenic activation and induces endoplasmic reticulum stress, while improving systemic metabolism and thermoregulation via ATF4-FGF21-dependent and -independent mechanisms.
    1. Computational and Systems Biology

    A convolutional neural network for the prediction and forward design of ribozyme-based gene-control elements

    Calvin M Schmidt, Christina D Smolke
    Machine learning has been applied to develop predictive models for designing RNA gene-control elements with targeted gene-regulatory activities.

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