498 results found
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    A continuum model of transcriptional bursting

    Adam M Corrigan et al.
    Rather than switching between discrete on and off states, gene transcription exists in a spectrum or continuum of states, with a slowly changing initiation rate modulating the levels of activity.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Kinetic sculpting of the seven stripes of the Drosophila even-skipped gene

    Augusto Berrocal et al.
    Live quantitative monitoring of transcriptional bursting reveals that enhancers responding to different regulators use the same kinetic strategy to produce a complex composite pattern of developmental expression.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Loss of Kat2a enhances transcriptional noise and depletes acute myeloid leukemia stem-like cells

    Ana Filipa Domingues et al.
    Histone acetyl-transferase Kat2a preserves leukemia stem cells through frequent transcriptional firing of metabolic and regulatory gene promoters and maintenance of a largely invariant self-renewal program.
    1. Neuroscience

    Distinct stages of synapse elimination are induced by burst firing of CA1 neurons and differentially require MEF2A/D

    Chia-Wei Chang et al.
    Increasing periods of neuronal activity progressively weaken and then eliminate synapses through the activation of specific transcription factors and genes.
    1. Developmental Biology

    The Wg and Dpp morphogens regulate gene expression by modulating the frequency of transcriptional bursts

    Rachael Bakker et al.
    Experimental results in Drosophila support a model in which gene expression is fundamentally controlled by morphogens tuning the same transcription parameter for genes that are expressed in highly diverse patterns.
    1. Computational and Systems Biology
    2. Developmental Biology

    Control of tissue development and cell diversity by cell cycle-dependent transcriptional filtering

    Maria Abou Chakra et al.
    A mathematical model predicts that cell cycle duration acts as a transcriptional filter and directly affects cell diversity in early eukaryotic development.
    1. Developmental Biology

    Ordered patterning of the sensory system is susceptible to stochastic features of gene expression

    Ritika Giri et al.
    How gene expression noise is regulated is critical for cell fate and tissue patterning.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Shadow enhancers can suppress input transcription factor noise through distinct regulatory logic

    Rachel Waymack et al.
    Proper development depends on establishing precise gene expression patterns in spite of the inherent noise in transcription, shadow enhancers buffer this noise by binding distinct input transcription factors.
    1. Cell Biology
    2. Computational and Systems Biology

    Spatially coordinated dynamic gene transcription in living pituitary tissue

    Karen Featherstone et al.
    Quantitative statistical modelling reveals local coordination of stochastic gene transcription dynamics in pituitary tissue, which is relevant for integrated tissue responses to physiological stimuli.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Single-cell RNA-seq reveals transcriptomic heterogeneity mediated by host–pathogen dynamics in lymphoblastoid cell lines

    Elliott D SoRelle et al.
    Single-cell RNA sequencing highlights the influence of host–pathogen interactions and stochasticity on transcriptional and phenotypic variance in lymphoblastoid cell lines derived from Epstein–Barr virus-infected primary B cells.

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