3,600 results found
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    YAP and TAZ are transcriptional co-activators of AP-1 proteins and STAT3 during breast cellular transformation

    Lizhi He et al.
    YAP and TAZ, the ultimate targets of the Hippo signaling pathway, are transcriptional co-activators of AP-1 proteins and STAT3 through which they are important for breast cellular transformation.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Evolution of reduced co-activator dependence led to target expansion of a starvation response pathway

    Bin Z He et al.
    The phosphate starvation response network in a commensal yeast evolved to expand its downstream targets via changes in the main transcription factor's dependence on its co-activator, potentially altering the physiological response.
    1. Cancer Biology
    2. Cell Biology

    Regulation of localization and function of the transcriptional co-activator YAP by angiomotin

    Susana Moleirinho et al.
    Phosphorylation of Angiomotin regulates YAP localization and activity.
    1. Developmental Biology

    Sox17 and β-catenin co-occupy Wnt-responsive enhancers to govern the endoderm gene regulatory network

    Shreyasi Mukherjee et al.
    Genomic analysis of Xenopus gastrula reveal that the transcription factor Sox17 interacts with the Wnt signaling effector ß-catenin on enhancers to regulate the transcriptional program underlying endoderm germ layer formation.
    1. Microbiology and Infectious Disease

    Chromatin mapping identifies BasR, a key regulator of bacteria-triggered production of fungal secondary metabolites

    Juliane Fischer et al.
    Genome-wide chromatin mapping during bacterial-fungal cocultivation identifies the Myb-like transcription factor BasR as the major regulatory node of bacteria-triggered production of fungal secondary metabolites.
    1. Chromosomes and Gene Expression

    Distinct modes of SMAD2 chromatin binding and remodeling shape the transcriptional response to NODAL/Activin signaling

    Davide M Coda et al.
    NODAL/Activin-induced SMAD2 binding directly drives remodeling of both open and closed chromatin and does not directly correlate with temporal patterns of gene expression upon prolonged signaling.
    1. Stem Cells and Regenerative Medicine

    CtBP impedes JNK- and Upd/STAT-driven cell fate misspecifications in regenerating Drosophila imaginal discs

    Melanie I Worley et al.
    The CtBP protein stabilizes cell fates in regenerating tissue.
    1. Developmental Biology
    2. Neuroscience

    A terminal selector prevents a Hox transcriptional switch to safeguard motor neuron identity throughout life

    Weidong Feng et al.
    A molecular mechanism that involves highly conserved transcription factors enables cholinergic motor neurons of the nematode Caenorhabditis elegans to become and remain functional.
    1. Developmental Biology
    2. Neuroscience

    Retrograde Ret signaling controls sensory pioneer axon outgrowth

    Adam Tuttle et al.
    Long-range Ret receptor signaling promotes axon outgrowth and regulates growth cone dynamics in pioneer neurons by inducing transcriptional changes in Myosin-X expression.
    1. Structural Biology and Molecular Biophysics

    An order-to-disorder structural switch activates the FoxM1 transcription factor

    Aimee H Marceau et al.
    Structural and biochemical analysis reveals that two intrinsically disordered domains of the transcription factor FoxM1 co-fold to form an autoinhibited conformation, which is disrupted by a specific activating phosphorylation event.

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