4,703 results found
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Quality control of transcription start site selection by nonsense-mediated-mRNA decay

    Christophe Malabat et al.
    RNA polymerase II generates numerous transcript isoforms, including transcripts initiating downstream of the START codon, that are efficiently degraded by the nonsense-mediated mRNA decay pathway.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    A single-parasite transcriptional atlas of Toxoplasma Gondii reveals novel control of antigen expression

    Yuan Xue et al.
    Single-cell RNA-sequencing resolves the transcriptional landscape of asexual development in Toxoplasma gondii, revealing concerted genetic programs to Plasmodiumfalciparum and a novel transcriptional factor that controls antigen switching.
    1. Developmental Biology
    2. Plant Biology

    Control of plant cell fate transitions by transcriptional and hormonal signals

    Christophe Gaillochet et al.
    HEC transcription factors control the timing of cell fate transitions in a dynamic stem cell system, allowing plants to adapt their developmental program to diverse environments.
    1. Developmental Biology

    Zfp281 is essential for mouse epiblast maturation through transcriptional and epigenetic control of Nodal signaling

    Xin Huang et al.
    Post-implantation epiblast maturation and patterning of anterior-posterior axis in mouse embryonic development are mediated by pluripotency transcription factor Zfp281 through transcriptional and epigenetic control of Nodal signaling.
    1. Developmental Biology

    Identification of the transcription factor ZEB1 as a central component of the adipogenic gene regulatory network

    Carine Gubelmann et al.
    A large-scale transcription factor screen reveals over twenty novel adipogenic regulators: most notably ZEB1, which exerts essential transcriptional control of fat cell differentiation.
    1. Microbiology and Infectious Disease

    An NAD+-dependent novel transcription factor controls stage conversion in Entamoeba

    Dipak Manna et al.
    Cellular NAD+ levels change during stage conversion and regulate function of a novel transcription factor that controls developmental switching in the human pathogen Entamoeba histolytica.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    The splicing regulator PTBP1 controls the activity of the transcription factor Pbx1 during neuronal differentiation

    Anthony J Linares et al.
    The RNA binding protein PTBP1 controls an extensive program of alternative splicing in embryonic stem cells, one function of which is to repress neuronal transcriptional programs.
    1. Chromosomes and Gene Expression

    HIV Tat controls RNA Polymerase II and the epigenetic landscape to transcriptionally reprogram target immune cells

    Jonathan E Reeder et al.
    Tat uses unexpected regulatory mechanisms to reprogram target immune cells to promote viral replication and rewire pathways beneficial for HIV.
    1. Developmental Biology

    The Hippo effector Yorkie activates transcription by interacting with a histone methyltransferase complex through Ncoa6

    Yun Qing et al.
    Elucidating the molecular mechanism by which the Hippo signaling effector Yorkie (Yki) functions as a transcriptional coactivator in growth control reveals the importance of a histone-modifying enzyme for this process.
    1. Genetics and Genomics

    Multi-species, multi-transcription factor binding highlights conserved control of tissue-specific biological pathways

    Benoit Ballester et al.
    Combinatorial transcription factor binding shared by multiple species enriches for essential biological pathways and coincides with disease-causing regulatory DNA mutations.

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