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    1. Genetics and Genomics

    An ancient competition for the conserved branchpoint sequence influences physiological and evolutionary outcomes in splicing

    Karen Larissa Pereira de Castro, Jose M Abril ... W Samuel Fagg
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cell Biology
    2. Developmental Biology

    Glypicans define unique roles for the Hedgehog co-receptors boi and ihog in cytoneme-mediated gradient formation

    Eléanor Simon, Carlos Jiménez-Jiménez ... Isabel Guerrero
    The glypicans Dally-like protein and Dally reveal functional non-redundancy of the Hedgehog co-receptors Boi and Ihog through independent interactions and specifically regulate cytoneme dynamics via the Ihog FNIII domain, thus setting long-range signaling.
    1. Developmental Biology

    Fat body-derived cytokine Upd2 controls disciplined migration of tracheal stem cells in Drosophila

    Pengzhen Dong, Yue Li ... Hai Huang
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Allosteric inhibition of trypanosomatid pyruvate kinases by a camelid single-domain antibody

    Joar Esteban Pinto Torres, Mathieu Claes ... Yann G.-J Sterckx
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Predicting bacterial promoter function and evolution from random sequences

    Mato Lagator, Srdjan Sarikas ... Gašper Tkačik
    An inferred mechanistic model that connects sequence (genotype) to function (constitutive gene expression phenotype) for any random sequence in Escherichia coli reveals the structure of constitutive promoters and how they evolve.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling

    Sigrid Nachtergaele, Daniel M Whalen ... Rajat Rohatgi
    A cysteine-rich domain within the Smoothened receptor may represent a novel therapeutic target for cancers caused by abnormal functioning of the Hedgehog signaling pathway.
    1. Microbiology and Infectious Disease

    Acute targeted induction of gut-microbial metabolism affects host clock genes and nocturnal feeding

    Giorgia Greter, Claudia Moresi ... Markus Arnoldini
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Cell Biology
    2. Developmental Biology

    The NDNF-like factor Nord is a Hedgehog-induced extracellular BMP modulator that regulates Drosophila wing patterning and growth

    Shu Yang, Xuefeng Wu ... Xiaoyan Zheng
    The NDNF-like factor Nord is a Hedgehog-induced and extracellular-localized dosage-dependent BMP modulator that regulates Drosophila wing patterning and growth.
    1. Stem Cells and Regenerative Medicine

    Prospective identification of functionally distinct stem cells and neurosphere-initiating cells in adult mouse forebrain

    John K Mich, Robert AJ Signer ... Sean J Morrison
    Flow cytometric isolation and fate mapping shows that neurosphere-initiating cells are highly mitotically active and persist only transiently in vivo, and are distinct from quiescent, long-lived neural stem cells.
    1. Medicine
    2. Microbiology and Infectious Disease

    HERV activation segregates ME/CFS from fibromyalgia while defining a novel nosologic entity

    Karen Giménez-Orenga, Eva Martín-Martínez ... Elisa Oltra
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
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