Newly prepared double gene-edited sheep provide excellent models for skeletal muscle growth and development, and muscle diseases such as muscle atrophy and sarcopenia.
Inhibition of ITGA2-mediated cancer cell-collagen interaction or targeting focal adhesion kinase activity may present an opportunity for therapeutic intervention of metastatic spread in ovarian cancer.
Over 2.8 million tissue-specific gene regulatory sequences are predicted for 33 insect genomes, using a simple computational workflow with only the genome sequence and a basic gene annotation as input.
Single-cell data on cell signaling responses to nutrient variation enable quantitative models of cellular control over protein synthesis, formalizing the concept of mTOR as a homeostatic controller of cellular metabolism.
Genetic analyses and biochemical studies show that JMJD6 promotes MYC-mediated transformation and is required for neuroblastoma growth by complexing with pre-mRNA splicing factors.
ZCWPW1 has co-evolved with PRDM9, in particular the PRDM9-SET domain, and although not involved in PRDM9's role in positioning recombination events, it is required for PRDM9's role in pairing chromosomes.
