Acetylcholine, released from cholinergic fibers originating from the medial septum, shapes social memory, and controls the CA2 hippocampal circuit via nicotinic receptors localized on GABAergic interneurons.
Alternative splicing and the endoplasmic reticulum (ER)-associated protein degradation (ERAD) system represent essential, fat depot-specific components of the adipogenesis that are altered in preadipocytes from obese individuals with metabolic disease.
A proteomics-based approach identifies novel substrate proteins of the Lon protease in Caulobacter crescentus and reveals a critical role of Lon in regulating flagella assembly and stalk biogenesis during the cell cycle.
Somatic stem and niche cells in the Drosophila ovary develop from common precursors through regulated proliferative expansion, followed by acquisition of position-specific behaviors, rather than through rigid early specification events.
Single-molecule fluorescence experiments reveal transcription initiation proceeds via a 'bind-unwind-load-and-lock' mechanism where promoter DNA unwinds outside the RNA polymerase (RNAP) cleft, the unwound template-DNA loads into the cleft, and RNAP 'locks' the template-DNA by closing the RNAP clamp module.
Data exploring host and parasite signatures in the peripheral blood indicate that total parasite biomass is a better predictor of P. vivax-induced host responses and pathogenesis than peripheral parasitemia.
Retinal pigment epithelium flattening is an efficient solution adopted by the fast-developing zebrafish to enable folding of the eye primordia, which contrasts with the proliferation-based mechanism used by amniotes.
A parsimonious biophysical model correctly predicts the conserved expression stoichiometry of core bacterial mRNA translation factors, providing intuitive and quantitative design principles for in vivo pathway construction.