1,103 results found
    1. Cell Biology

    Spatial organization shapes the turnover of a bacterial transcriptome

    Jeffrey R Moffitt et al.
    Transcriptome-scale RNA imaging and lifetime measurements reveal that the E. coli transcriptome is spatially organized and that this organization modulates the post-transcriptional fate of bacterial mRNAs.
    1. Biochemistry and Chemical Biology

    A reverse transcriptase ribozyme

    Biswajit Samanta, Gerald F Joyce
    An RNA enzyme is shown to function as a reverse transcriptase, an activity thought to be crucial for the transition from RNA to DNA genomes during the early history of life on Earth.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Heterochromatin assembly and transcriptome repression by Set1 in coordination with a class II histone deacetylase

    David R Lorenz et al.
    Set1 has roles in chromatin organization and transcriptome control that are largely independent of histone H3 lysine 4 methylation.
    1. Developmental Biology
    2. Human Biology and Medicine

    An integrative transcriptomic atlas of organogenesis in human embryos

    Dave T Gerrard et al.
    Integrating human embryonic transcriptomes from 15 sites during organogenesis identifies novel expression signatures linked to congenital disorders and a new programme of non-coding gene expression.
    1. Structural Biology and Molecular Biophysics

    Asymmetric conformational maturation of HIV-1 reverse transcriptase

    Xunhai Zheng et al.
    HIV-1 reverse transcriptase uses a metamorphic polymerase domain that minimizes its coding requirements but requires a complex maturation process.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    A new view of transcriptome complexity and regulation through the lens of local splicing variations

    Jorge Vaquero-Garcia et al.
    New methods reveal that complex local splicing variations are more prevalent in animals than previously appreciated, and demonstrate that local splicing variations are relevant for studies of development, gene regulation and neurodegenerative diseases.
    1. Neuroscience

    Hypocretin neuron-specific transcriptome profiling identifies the sleep modulator Kcnh4a

    Laura Yelin-Bekerman et al.
    Comprehensive gene profiling of the hypothalamic hypocretin neurons, high resolution imaging and behavioral assays have revealed the molecular signature of these versatile neurons and identified a potassium channel that is required for nighttime sleep.
    1. Computational and Systems Biology
    2. Developmental Biology

    The transcriptomic and epigenetic map of vascular quiescence in the continuous lung endothelium

    Katharina Schlereth et al.
    The acquisition of vascular quiescence during transition to adulthood is driven by distinct transcriptional and epigenetic programs of pro- and anti-angiogenic genes, with the most prominent effect on the suppression of TGFß family signaling.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Transcriptomic and proteomic landscape of mitochondrial dysfunction reveals secondary coenzyme Q deficiency in mammals

    Inge Kühl et al.
    Comparative -omic analyses of five knockout mouse strains with disrupted mitochondrial DNA expression at different levels provide a high quality resource of altered gene expression patterns that reveal several common secondary patophysiological changes of mitochondrial dysfunction.
    1. Plant Biology

    Temporal network analysis identifies early physiological and transcriptomic indicators of mild drought in Brassica rapa

    Kathleen Greenham et al.
    Coupled physiology and gene expression, measured over a two-day time course, reveals specific time-of-day responses to the early stages of drought in Brassica rapa.

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