1,423 results found
    1. Plant Biology

    Dynamic ubiquitination determines transcriptional activity of the plant immune coactivator NPR1

    Michael J Skelly et al.
    Expression of plant immune genes is controlled by the opposing actions of ubiquitin ligases and deubiquitinases that modify the master coactivator NPR1, thereby regulating its intrinsic transcriptional activity.
    1. Evolutionary Biology

    The Natural History of Model Organisms: Insights into the evolution of social systems and species from baboon studies

    Julia Fischer et al.
    Wild baboons are an excellent model to study complex evolutionary processes such as speciation and hybridization, as well as the links between sociality, longevity and reproductive success.
    1. Chromosomes and Gene Expression

    CTCF confers local nucleosome resiliency after DNA replication and during mitosis

    Nick Owens et al.
    In contrast to other transcription factors, CTCF and Esrrb rapidly regain binding after replication and remain bound to their targets during mitosis, preserving local nucleosome organization throughout the cell cycle.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Screening identifies small molecules that enhance the maturation of human pluripotent stem cell-derived myotubes

    Sridhar Selvaraj et al.
    Treatment of human pluripotent stem cell-derived myotubes with a cocktail of small molecules induces their maturation, as shown by gene expression, biochemical and functional assays.
    1. Microbiology and Infectious Disease

    Discrete viral E2 lysine residues and scavenger receptor MARCO are required for clearance of circulating alphaviruses

    Kathryn S Carpentier et al.
    The scavenger receptor MARCO and liver phagocytes are required for clearance of circulating alphavirus particles and thereby limit viremia and viral dissemination.
    1. Neuroscience

    Novel long-range inhibitory nNOS-expressing hippocampal cells

    Zoé Christenson Wick et al.
    An intersectional genetic vector approach allows the identification and characterization of novel hippocampal inhibitory neurons with both broad local connectivity within CA1 and long-range projections to several extrahippocampal areas.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    SCGN deficiency results in colitis susceptibility

    Luis F Sifuentes-Dominguez et al.
    A novel mutation in SCGN is associated with risk for inflammatory bowel disease and implicates the intestinal neuroendocrine compartment in the pathogenesis of this disorder.
    1. Cell Biology
    2. Human Biology and Medicine

    Single cell analysis reveals immune cell–adipocyte crosstalk regulating the transcription of thermogenic adipocytes

    Prashant Rajbhandari et al.
    Crosstalk between IL10-producing immune cells and adipocytes within adipose tissue is an important determinant of thermogenesis and systemic energy balance.

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