Loss-of-function screening identified transglutaminase 2 (TGM2) as a putative tumor suppressor in the TP53 pathway and revealed that TGM2-mediated autophagy and CDKN1A-mediated cell cycle arrest are two critical barriers that prevent oncogenic transformation.
ST recruitment of STRIPAK facilitates PP2A-mediated dephosphorylation of MAP4K4 and induces cell transformation highlighting that STRIPAK complex plays a key role in defining PP2A specificity and activity.
Neuronal recordings from rat visual cortex reveal an object-processing pathway, along which neuronal representations become increasingly capable of supporting recognition of visual objects in spite of variation in their appearance.
The spatial and dynamic properties of self-motion signals are acquired at the first stage of otolith signal transformation, which is in the brainstem and cerebellum, and conserved across brainstem, cerebellar and cortical areas.
A spiking network model that examines the transformation of odor information from olfactory bulb to piriform cortex demonstrates how intrinsic cortical circuitry preserves representations of odor identity across odorant concentrations.