Loss-of-function screening identified transglutaminase 2 (TGM2) as a putative tumor suppressor in the TP53 pathway and revealed that TGM2-mediated autophagy and CDKN1A-mediated cell cycle arrest are two critical barriers that prevent oncogenic transformation.
ST recruitment of STRIPAK facilitates PP2A-mediated dephosphorylation of MAP4K4 and induces cell transformation highlighting that STRIPAK complex plays a key role in defining PP2A specificity and activity.
An extended border coding circuit across the entorhinal and retrosplenial cortex incorporates self-referenced and viewpoint-invariant boundary information to guide navigation behavior.
Neuronal recordings from rat visual cortex reveal an object-processing pathway, along which neuronal representations become increasingly capable of supporting recognition of visual objects in spite of variation in their appearance.
DNA uptake and recombination in pneumococcus are highly efficient and independent of the cell-cycle or genetic location of the transformed allele, but limited to maximally 50% of the population.
Peripheral injury induces a programmed but reversible transformation of gene expression in somatosensory neurons providing a mechanism to regulate sensory input during wound healing.
The spatial and dynamic properties of self-motion signals are acquired at the first stage of otolith signal transformation, which is in the brainstem and cerebellum, and conserved across brainstem, cerebellar and cortical areas.
A spiking network model that examines the transformation of odor information from olfactory bulb to piriform cortex demonstrates how intrinsic cortical circuitry preserves representations of odor identity across odorant concentrations.
