2,204 results found
    1. Ecology

    Genetic transformation of the dinoflagellate chloroplast

    Isabel C Nimmo et al.
    Successful stable transformation of the dinoflagellate chloroplast genome.
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation

    Shi Yun Yeo et al.
    Loss-of-function screening identified transglutaminase 2 (TGM2) as a putative tumor suppressor in the TP53 pathway and revealed that TGM2-mediated autophagy and CDKN1A-mediated cell cycle arrest are two critical barriers that prevent oncogenic transformation.
    1. Cancer Biology

    STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells

    Jong Wook Kim et al.
    ST recruitment of STRIPAK facilitates PP2A-mediated dephosphorylation of MAP4K4 and induces cell transformation highlighting that STRIPAK complex plays a key role in defining PP2A specificity and activity.
    1. Cancer Biology
    2. Cell Biology

    Human pancreatic cancer cell exosomes, but not human normal cell exosomes, act as an initiator in cell transformation

    Karoliina Stefanius et al.
    Exosomes secreted from pancreatic cancer cells can function as a classic initiator in the multi-step cellular transformation process.
    1. Neuroscience

    Entorhinal-retrosplenial circuits for allocentric-egocentric transformation of boundary coding

    Joeri BG van Wijngaarden et al.
    An extended border coding circuit across the entorhinal and retrosplenial cortex incorporates self-referenced and viewpoint-invariant boundary information to guide navigation behavior.
    1. Neuroscience

    Emergence of transformation-tolerant representations of visual objects in rat lateral extrastriate cortex

    Sina Tafazoli et al.
    Neuronal recordings from rat visual cortex reveal an object-processing pathway, along which neuronal representations become increasingly capable of supporting recognition of visual objects in spite of variation in their appearance.
    1. Microbiology and Infectious Disease

    Unbiased homeologous recombination during pneumococcal transformation allows for multiple chromosomal integration events

    Jun Kurushima et al.
    DNA uptake and recombination in pneumococcus are highly efficient and independent of the cell-cycle or genetic location of the transformed allele, but limited to maximally 50% of the population.
    1. Neuroscience

    Stereotyped transcriptomic transformation of somatosensory neurons in response to injury

    Minh Q Nguyen et al.
    Peripheral injury induces a programmed but reversible transformation of gene expression in somatosensory neurons providing a mechanism to regulate sensory input during wound healing.
    1. Neuroscience

    Transformation of spatiotemporal dynamics in the macaque vestibular system from otolith afferents to cortex

    Jean Laurens et al.
    The spatial and dynamic properties of self-motion signals are acquired at the first stage of otolith signal transformation, which is in the brainstem and cerebellum, and conserved across brainstem, cerebellar and cortical areas.
    1. Neuroscience

    A transformation from temporal to ensemble coding in a model of piriform cortex

    Merav Stern et al.
    A spiking network model that examines the transformation of odor information from olfactory bulb to piriform cortex demonstrates how intrinsic cortical circuitry preserves representations of odor identity across odorant concentrations.

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