58 results found
    1. Computational and Systems Biology

    A unified framework for measuring selection on cellular lineages and traits

    Shunpei Yamauchi, Takashi Nozoe ... Yuichi Wakamoto
    A unified framework for cell lineage statistics enables quantification of fitness landscapes and selection strength for any cellular lineage traits in a model-independent manner, and reveals the contributions of growth heterogeneity to population growth in diverse experimental model systems.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Drivers and sites of diversity in the DNA adenine methylomes of 93 Mycobacterium tuberculosis complex clinical isolates

    Samuel J Modlin, Derek Conkle-Gutierrez ... Faramarz Valafar
    Fully assembled DNA methylomes from phylogeographically diverse clinical Mycobacterium tuberculosis complex isolates reveals 'intercellular mosaic methylation' as a source of epigenetic diversity.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Maternally inherited piRNAs direct transient heterochromatin formation at active transposons during early Drosophila embryogenesis

    Martin H Fabry, Federica A Falconio ... Gregory J Hannon
    Maternally deposited Piwi-piRNA complexes co-transcriptionally repress transposable elements that transiently become active in somatic cells of the developing Drosophila embryo.
    1. Developmental Biology
    2. Genetics and Genomics

    Determining the effects of paternal obesity on sperm chromatin at histone H3 lysine 4 tri-methylation in relation to the placental transcriptome and cellular composition

    Anne-Sophie Pepin, Patrycja A Jazwiec ... Sarah Kimmins
    Epigenomic and transcriptomic analysis reveals that paternal obesity influences sperm histone H3 lysine 4 tri-methylation enrichment and placenta gene expression, which in turn negatively impact its development and function in a manner that may contribute to metabolic disease in offspring.
    1. Evolutionary Biology
    2. Immunology and Inflammation

    Evolution of pathogen tolerance and emerging infections: A missing experimental paradigm

    Srijan Seal, Guha Dharmarajan, Imroze Khan
    An integrated empirical paradigm tracing immune strategies, underlying mechanisms and infection outcomes across reservoir host-pathogen systems, their specific ecological contexts, life-history features, and coevolutionary dynamics can reveal the actual patterns and processes underlying spillover in the wild.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Onset of taste bud cell renewal starts at birth and coincides with a shift in SHH function

    Erin J Golden, Eric D Larson ... Linda A Barlow
    Taste cell renewal begins at birth and is promoted by sonic hedgehog that alters the expression of regulators of cell migration and adhesion that may allow entry of new cells into buds.
    1. Ecology
    2. Evolutionary Biology

    Intergenerational effects of early adversity on survival in wild baboons

    Matthew N Zipple, Elizabeth A Archie ... Susan C Alberts
    In wild baboons, a female's adverse early experiences can influence her offspring's survival years after the original adversity was experienced.
    1. Chromosomes and Gene Expression

    Intergenerational epigenetic inheritance of cancer susceptibility in mammals

    Bluma J Lesch, Zuzana Tothova ... David C Page
    Genetic knockout of the histone demethylase Kdm6a in the mouse germ line leads to elevated cancer incidence in genetically wild type offspring.
    1. Ecology
    2. Microbiology and Infectious Disease

    Host-microbiome metabolism of a plant toxin in bees

    Erick VS Motta, Alejandra Gage ... Nancy Moran
    The bee gut microbiota contributes to the metabolism of the cyanogenic glycoside amygdalin.
    1. Cell Biology
    2. Genetics and Genomics

    Regulation of defective mitochondrial DNA accumulation and transmission in C. elegans by the programmed cell death and aging pathways

    Sagen Flowers, Rushali Kothari ... Joel H Rothman
    Mitochondrial quality control in the germline is mediated by regulators of both programmed cell death and the aging program.

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