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    1. Evolutionary Biology
    2. Genetics and Genomics

    Predominance of cis-regulatory changes in parallel expression divergence of sticklebacks

    Jukka-Pekka Verta, Felicity C Jones
    Cis-regulation such as enhancers and promoters plays a major role in parallel gene expression divergence and has features that make it a well-poised substrate for adaptive evolution.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Nongenetic inheritance and multigenerational plasticity in the nematode C. elegans

    L Ryan Baugh, Troy Day
    Evidence is mounting that environmentally-induced adaptive changes in phenotype can be transmitted across generations, but mechanistic gaps and theoretical concerns must be addressed to impact mainstream views of evolutionary adaptation.
    1. Cell Biology

    Serotonin signaling by maternal neurons upon stress ensures progeny survival

    Srijit Das et al.
    Neuronal serotonin release tunes transcription response times of Caenorhabditis elegans germ cells to promote the survival and stress resistance of future offspring.
    1. Neuroscience

    Internal states drive nutrient homeostasis by modulating exploration-exploitation trade-off

    Verónica María Corrales-Carvajal et al.
    A quantitative video tracking analysis reveals that to gain the nutrients they need, flies change their decisions to exploit foods with different nutrient contents and explore the environment according to their internal amino acid and reproductive states.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    The TRIM-NHL protein NHL-2 is a co-factor in the nuclear and somatic RNAi pathways in C. elegans

    Gregory M Davis et al.
    The RNA-binding protein NHL-2 is required for small-RNA mediated transgenerational epigenetic gene regulation.
    1. Cell Biology
    2. Developmental Biology

    Maternal spindle transfer overcomes embryo developmental arrest caused by ooplasmic defects in mice

    Nuno Costa-Borges et al.
    Maternal spindle transfer is a feasible approach to enhance embryonic developmental of compromised oocytes, which can represent a new strategy for patients with forms of infertility refractory to current treatments.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Control of RNA viruses in mosquito cells through the acquisition of vDNA and endogenous viral elements

    Michel Tassetto et al.
    Virus infection in mosquitoes initiates a highly discriminatory process in which fragments of viral RNA are reverse transcribed to create DNA copies that serve as templates of small antiviral RNAs.
    1. Ecology

    Adaptive thermal plasticity enhances sperm and egg performance in a model insect

    Ramakrishnan Vasudeva et al.
    Sperm and egg development are temperature sensitive, enabling males and females to significantly improve their reproductive success by matching gamete function to varying thermal environments for fertilisation and offspring development.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Epigenetics: A memory of longevity

    Felicity Emerson et al.
    Worms with increased levels of the epigenetic mark H3K9me2 have a longer lifespan that can be passed down to future generations.
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    1. Developmental Biology

    p53 activity is selectively licensed in the Drosophila stem cell compartment

    Annika Wylie et al.
    Ancient features of the p53 regulatory network are coupled to the stem cell compartment in normal and pathologic contexts.