Transport of double-stranded RNA from parental circulation to progeny using the transmembrane protein SID-1 can occur through multiple routes during C. elegans development and buffer heritable changes in gene expression.

Epigenomic and transcriptomic analysis reveals that paternal obesity influences sperm histone H3 lysine 4 tri-methylation enrichment and placenta gene expression, which in turn negatively impact its development and function in a manner that may contribute to metabolic disease in offspring.

Aphid and mildew read counts leftover from the sequencing of greenhouse plants correlated with the environment of origin of the plants, and allowed the mapping of pathogen resistance genes.

Maternal obesity mouse model reveal that melatonin deficiency causes the genomic hyper-methylation of oocytes via increasing the expression of DNA methyltransferases.

Despite no observed correlation between retrotransposon (RTE) activity and chronological age, the expression of most RTE classes and families except SINEs correlated with biological age-associated gene signature scores.

The utility of an in vitro cell culture system for studies of molecular mechanisms underlying the initial induction and subsequent propagation of environmentally induced epimutations is demonstrated.

Large extracellular vesicle extrusion that eliminates neuronal protein aggregates and organelles is potentiated by uterine filling, linking reproductive status to maternal nervous system health, and demonstrating mechanobiology components in exophergenesis.

A foundation for analyzing epigenetic changes within the context of regulatory architectures that enable heredity.