The METHYL-CpG-BINDING DOMAIN 7 (MBD7) complex promotes the activation (rather than repression) of transgenes that undergo DNA methylation and it does so without significantly altering their methylation status, placing this complex downstream of DNA methylation.

Transfection of quail primordial germ cells considerably expands the possibilities of genome modifications in birds, elevating the quail to the rank of genetic laboratory animal models of reference.

In transgenesis assays involving diploid model organisms, two clearly distinguishable transformation markers embedded in interweaved, but incompatible Lox site pairs allow the systematic creation of homozygous transgenic lines and minimize the number of wasted animals.

A new viral injection method targets the transverse sinuses to achieve robust whole-brain delivery of single or multiple genes in multiple mammalian species early in development.

The information for mRNAs expression level is set by codon choice in trypanosomes and requires translation to be interpreted into a turnover rate.

Developmental regulatory mechanisms for peripheral nervous system formation appear to be conserved in ascidians despite extensive genomic divergence after 390 MY of separate evolution.

A chromosome-wide mechanism balances X-linked gene expression between the sexes in C. elegans, but no similar chromosome-wide mechanism balances gene expression between X chromosomes and autosomes.

A novel transposon-based enhancer trap screen in mice permits high throughput development of highly restricted driver strains targeting specific neuronal cell types.

Expression of almost half of a library of fluorescent reporters distinguish long- from short-lived individual Caenorhabditis elegans, suggesting that organism-wide differences in gene expression drive future lifespan.

Building on previous work (Cai et al., 2014), HIV-derived lentiviral vectors are harnessed to insert user-defined genes into a safe locus in the genome of human stem cells.