243 results found
    1. Neuroscience

    Central Dicer-miR-103/107 controls developmental switch of POMC progenitors into NPY neurons and impacts glucose homeostasis

    Sophie Croizier et al.
    Loss miRNA maturation in proopiomelanocortin (POMC) neurons causes metabolic dysregulation and favors the differentiation of Pomc progenitors into neuropeptide Y neurons, a developmental process that appears to specifically involve miR-103/107.
    1. Developmental Biology

    A vitamin-B2-sensing mechanism that regulates gut protease activity to impact animal’s food behavior and growth

    Bin Qi et al.
    The availability of an essential dietary micronutrient is evaluated by an intestinal signaling system that in turn regulates food-uptake and response behaviors by modulating protease expression.
    1. Developmental Biology
    2. Human Biology and Medicine

    Erythropoietin signaling regulates heme biosynthesis

    Jacky Chung et al.
    EPO/JAK2/PKA signaling cascade via AKAP10 relocalization to the outer mitochondrial membrane results in the phosphorylation of the terminal heme synthesis enzyme ferrochelatase, which contributes to heme production in red cells.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    The MBD7 complex promotes expression of methylated transgenes without significantly altering their methylation status

    Dongming Li et al.
    The METHYL-CpG-BINDING DOMAIN 7 (MBD7) complex promotes the activation (rather than repression) of transgenes that undergo DNA methylation and it does so without significantly altering their methylation status, placing this complex downstream of DNA methylation.
    1. Cell Biology
    2. Human Biology and Medicine

    A critical role for mTORC1 in erythropoiesis and anemia

    Zachary A Knight et al.
    Transcription profiling of activated cells using Phospho-Trap, a new method for identifying activated cells, reveals a critical role for mTOR signaling in red blood cell development and the pathogenesis of anemia
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Mi-2/NuRD complex protects stem cell progeny from mitogenic Notch signaling

    Evanthia Zacharioudaki et al.
    Depleting Mi-2 in the progeny of neural stem cells prevents normal enhancer decommissioning so that they become sensitive to Notch activity and re-acquire stem cell properties.
    1. Neuroscience

    PARIS, an optogenetic method for functionally mapping gap junctions

    Ling Wu et al.
    As the first fully genetically encoded method, PARIS allows cell-specific, long-term, repeated measurements of gap junctional coupling with high spatiotemporal resolution, facilitating its study in both health and disease.
    1. Evolutionary Biology

    Rapid diversification associated with a macroevolutionary pulse of developmental plasticity

    Vladislav Susoy et al.
    Evolutionary novelty is promoted by a macroevolutionary pulse of developmental plasticity, but is enhanced by secondary fixation, which permits developmental character release and further morphological exploration.
    1. Cell Biology
    2. Neuroscience

    Activity and Ca2+ regulate the mobility of TRPV1 channels in the plasma membrane of sensory neurons

    Eric N Senning, Sharona E Gordon
    Channel activity is a novel regulatory mechanism for channel mobility in the plasma membrane.
    1. Developmental Biology

    p53 activity is selectively licensed in the Drosophila stem cell compartment

    Annika Wylie et al.
    Ancient features of the p53 regulatory network are coupled to the stem cell compartment in normal and pathologic contexts.

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