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    1. Microbiology and Infectious Disease
    2. Plant Biology

    Viral-inducible Argonaute18 confers broad-spectrum virus resistance in rice by sequestering a host microRNA

    Jianguo Wu et al.
    The cooperative antiviral activity of two distinct AGO proteins could be exploited to provide a new strategy for controlling viral diseases in rice.
    1. Cell Biology

    An in vivo reporter for tracking lipid droplet dynamics in transparent zebrafish

    Dianne Lumaquin et al.
    A novel transgenic lipid droplet reporter in transparent casper zebrafish allows direct visualization of individual lipid droplets in a living animal.
    1. Evolutionary Biology

    Genetic transformation of Spizellomyces punctatus, a resource for studying chytrid biology and evolutionary cell biology

    Edgar M Medina et al.
    Spizellomycespunctatusis a genetically tractable chytrid and model organism for comparative cell biology for understanding evolution of the cell cycle, actin dynamics, and cellularization in fungi and early eukaryotes.
    1. Cancer Biology

    MYC and Twist1 cooperate to drive metastasis by eliciting crosstalk between cancer and innate immunity

    Renumathy Dhanasekaran et al.
    MYC and Twist1 drive metastasis by a novel non-cell-autonomous transcriptional mechanism of eliciting a cytokinome that mediates the crosstalk between cancer cells and macrophages, and its therapeutic blockade inhibits metastasis.
    1. Cancer Biology
    2. Genetics and Genomics

    Targets and genomic constraints of ectopic Dnmt3b expression

    Yingying Zhang et al.
    Ectopic expression of Dnmt3b leads to wide-spread CpG island hypermethylation that is largely defined by chromatin state and has some distinct features when compared to the cancer methylome.
    1. Neuroscience

    Suppression of C9orf72 RNA repeat-induced neurotoxicity by the ALS-associated RNA-binding protein Zfp106

    Barbara Celona et al.
    Zfp106 functions as an RNA binding protein, binds directly to GGGGCC RNA repeats, is required in motor neurons to prevent ALS-like neurodegeneration in mice, and can suppress neurotoxicity in an established fly model of ALS.
    1. Chromosomes and Gene Expression

    Chromosome-wide mechanisms to decouple gene expression from gene dose during sex-chromosome evolution

    Bayly S Wheeler et al.
    A chromosome-wide mechanism balances X-linked gene expression between the sexes in C. elegans, but no similar chromosome-wide mechanism balances gene expression between X chromosomes and autosomes.
    1. Cancer Biology
    2. Developmental Biology

    Myogenic regulatory transcription factors regulate growth in rhabdomyosarcoma

    Inês M Tenente et al.
    MYF5 and MYOD regulate rhabdomyosaroma growth and tumor-propagating potential, acting more than as passive markers retained from the target cell-of-origin during transformation.
    1. Cell Biology

    Adiponectin preserves metabolic fitness during aging

    Na Li et al.
    Adiponectin is an essential regulator for healthspan and is indispensable for sustaining a normal lifespan.
    1. Microbiology and Infectious Disease

    Rhabdo-immunodeficiency virus, a murine model of acute HIV-1 infection

    Rachel A Liberatore et al.
    A new animal model permits the in vivo study of HIV-1 entry, as well as the elicitation and antiviral activity of antibodies, in a genetically manipulatable host.