380 results found
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Novel transgenic pigs with enhanced growth and reduced environmental impact

    Xianwei Zhang, Zicong Li ... Zhenfang Wu
    Transgenic expression of glucanase, xylanase and phytase in pigs enhances growth performance and reduces nitrogen/phosphorus emission, and offers a very valuable biological strategy for sustainable resource utilization and environmental protection in the pork industry.
    1. Microbiology and Infectious Disease

    Transgenic shRNA pigs reduce susceptibility to foot and mouth disease virus infection

    Shengwei Hu, Jun Qiao ... Hongsheng Ouyang
    A transgenic small hairpin RNA can provide a viable tool for enhancing resistance to viral infection in livestock and improve animal well-being.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Pollution: Transgenic pigs to the rescue

    Björn Petersen
    Genetically engineered pigs that digest their food better could help to reduce phosphorus and nitrogen pollution.
    Version of Record
    Insight
    1. Developmental Biology

    Glycosylphosphatidylinositol biosynthesis and remodeling are required for neural tube closure, heart development, and cranial neural crest cell survival

    Marshall Lukacs, Tia Roberts ... Rolf W Stottmann
    Anchoring of proteins to the cell membrane through the glycosylphosphatidylinositol (GPI) anchor is critical for the survival of the cells that will give rise to the brain and face.
    1. Microbiology and Infectious Disease

    CD163 and pAPN double-knockout pigs are resistant to PRRSV and TGEV and exhibit decreased susceptibility to PDCoV while maintaining normal production performance

    Kui Xu, Yanrong Zhou ... Kui Li
    The double-gene-knockout pig is a valuable model to help understand the mechanisms of CD163 and pAPN in the infection of multiple viruses and offers excellent breeding materials for disease-resistant pigs.
    1. Epidemiology and Global Health
    2. Medicine

    Evaluating mesenchymal stem cell therapy for sepsis with preclinical meta-analyses prior to initiating a first-in-human trial

    Manoj M Lalu, Katrina J Sullivan ... Lauralyn McIntyre
    A rigorous and transparent evaluation of mesenchymal stem cell therapy for sepsis suggests it may be efficacious, although the strength of these findings is tempered by threats to validity in the studies that were included.
    1. Developmental Biology

    Pilot study of large-scale production of mutant pigs by ENU mutagenesis

    Tang Hai, Chunwei Cao ... Anming Meng
    ENU mutagenesis in pigs is an efficient strategy to introduce mutations at the whole-genome level and mutants have been generated on a large scale for agricultural production and biomedical research.
    1. Immunology and Inflammation

    CD47 cross-dressing by extracellular vesicles expressing CD47 inhibits phagocytosis without transmitting cell death signals

    Yang Li, Yan Wu ... Yong-Guang Yang
    Extracellular vesicles released from cells overexpressing CD47 mediate CD47 cross-dressing on surrounding cells, leading to protection against phagocytosis.

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