3,215 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mapping transiently formed and sparsely populated conformations on a complex energy landscape

    Yong Wang et al.
    Molecular simulations can capture key aspects of the conformational exchange in a protein.
    1. Structural Biology and Molecular Biophysics

    Thermal fluctuations of immature SOD1 lead to separate folding and misfolding pathways

    Ashok Sekhar et al.
    Solution NMR spectroscopy reveals the energy landscape of immature Cu, Zn-superoxide dismutase and leads to atomic resolution structural models of transiently populated non-native oligomers.
    1. Neuroscience

    Synchronized amplification of local information transmission by peripheral retinal input

    Pablo D Jadzinsky, Stephen A Baccus
    Peripheral retinal input transiently amplifies information transmission from ganglion cells, dynamically allocating the resources of neural activity to times of expected high information content.
    1. Structural Biology and Molecular Biophysics

    Structural Biology: NMR illuminates the pathways to ALS

    Tao Xie, Charalampos G Kalodimos
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    1. Microbiology and Infectious Disease

    Tropical Diseases: Can CRISPR help in the fight against parasitic worms?

    Paul McVeigh, Aaron G Maule
    The first reports of CRISPR/Cas9 genome editing in flatworms could usher in a new era of research on these dangerous human parasites.
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    1. Neuroscience

    Working Memory: Separating the present and the future

    Qing Yu, Bradley R Postle
    The brain stores information that is needed immediately and information that will be needed in the future in different ways.
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    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Circadian Rhythms: Feeding time

    Hugh D Piggins , David A Bechtold
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    1. Evolutionary Biology
    2. Structural Biology and Molecular Biophysics

    Protein Evolution: Building bigger beta-barrels

    Vikas Nanda
    The range of barrel-shaped proteins found in the outer membrane of certain bacteria evolved through multiple pathways.
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    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Reproducibility in Cancer Biology: Getting to grips with c-Myc

    Dirk Eick
    The transcription factor c-Myc amplifies the transcription of many growth-related genes in cancer cells, but its role as an oncogene is not fully understood.
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