8,534 results found
    1. Neuroscience

    Nonlinear transient amplification in recurrent neural networks with short-term plasticity

    Yue Kris Wu, Friedemann Zenke
    The interplay of recurrent excitation and short-term plasticity enables nonlinear transient amplification, an ideal mechanism for selective amplification, pattern completion, and pattern separation in recurrent neural networks.
    1. Medicine
    2. Neuroscience

    The mechanism underlying transient weakness in myotonia congenita

    Jessica H Myers, Kirsten Denman ... Mark M Rich
    Transient weakness in myotonia congenita is caused by depolarization secondary to activation of persistent Na+ current in skeletal muscle.
    1. Neuroscience

    The rate of transient beta frequency events predicts behavior across tasks and species

    Hyeyoung Shin, Robert Law ... Stephanie R Jones
    Across species, tasks and recording modalities, the rate of transient neocortical beta frequency (15-29Hz) events strongly predicts perceptual ability, providing fundamental mechanistic insight, with implications for tracking and manipulating brain dynamics.
    1. Neuroscience

    Firing rate-dependent phase responses of Purkinje cells support transient oscillations

    Yunliang Zang, Sungho Hong, Erik De Schutter
    Computational and theoretical models show that rate adaptation of phase responses can regulate Purkinje cell outputs by forming transient oscillations in fast-spiking neurons.
    1. Developmental Biology
    2. Neuroscience

    Activity-dependent death of transient Cajal-Retzius neurons is required for functional cortical wiring

    Martina Riva, Ioana Genescu ... Alessandra Pierani
    The complete elimination of a transient superficial population of neurons, and associated immature circuits, is required for the emergence of functional properties in the mature cerebral cortex.
    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    Multi-omic rejuvenation of human cells by maturation phase transient reprogramming

    Diljeet Gill, Aled Parry ... Wolf Reik
    Transiently reprogramming human fibroblasts up to the maturation phase rejuvenates cells according to several aging markers whilst enabling them to return to their original identity.
    1. Neuroscience

    Non-Hebbian plasticity transforms transient experiences into lasting memories

    Islam Faress, Valentina Khalil ... Sadegh Nabavi
    The process of transformation of a transient experience into a memory is neither restricted to the time of the experience nor to the synapses triggered by it, but it can be influenced by past and future events.
    1. Immunology and Inflammation

    Integrative analysis of scRNA-seq and scATAC-seq revealed transit-amplifying thymic epithelial cells expressing autoimmune regulator

    Takahisa Miyao, Maki Miyauchi ... Taishin Akiyama
    The combination of single-cell analysis and cell fate mapping studies evidenced the presence of AIRE-expressing transit-amplifying thymic epithelial cells, which differentiate into mature medullary thymic epithelial cells expressing tissue-specific antigens.
    1. Immunology and Inflammation

    The transcription factors Runx3 and ThPOK cross-regulate acquisition of cytotoxic function by human Th1 lymphocytes

    Yasmina Serroukh, Chunyan Gu-Trantien ... Arnaud Marchant
    The acquisition of cytotoxic function by human CD4 T cells is an integral part of the T helper 1 differentiation pathway and is limited by the transcription factor ThPOK.
    1. Neuroscience

    Transient inhibition and long-term facilitation of locomotion by phasic optogenetic activation of serotonin neurons

    Patrícia A Correia, Eran Lottem ... Zachary F Mainen
    Phasic activation of dorsal raphe serotonin neurons transiently inhibits locomotion without influencing anxiety or producing reinforcement, but when repeated over many days a long-term facilitation of locomotion is produced.

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