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Combination of experimental mouse models with single-cell RNA-sequencing creates a detailed map of medullary thymic epithelial cell development and identifies a transit-amplifying population as the immediate precursor to Aire-expressing mTECs.

Astrocyte microdomain calcium transients are mediated by TrpML, stimulated by ROS and tyramine, and mediate astrocyte–tracheal interactions in CNS gas exchange.

During development, lateral processes of retinal Müller glia are highly motile, and this motility persists when retinal waves and calcium transients are blocked, suggesting that Müller glial morphology is established independent of neuronal activity.

When translation stops, cells require intracellular acidification to turn on the conserved heat shock response during stress, and stress-triggered acidification (common in eukaryotes) is adaptive, promoting cell and population fitness.

Three months treatment with the drug rapamycin increases lifespan, alters cancer prevalence, remodels the microbiome, and improves functional measures of health in middle aged mice in a dose- and sex-dependent manner.

Building on previous work (Baker et al., 2015), further evidence is reported for a novel mechanism for sensory coding based on the detection of oscillatory synchrony among peripheral receptors.

Tumors escape killing by the immune system through generating transient spatial cell-in-cell structures that are impenetrable to cytotoxic compounds including lytic granules and chemotherapy.

Depiction of novel human genomic safe harbour loci that have been validated in vitro for safety and stable expression in human embryonic stem cells and cell types from all the three germ lineages.

Maturation of cortical network dynamics is characterized by a nadir that signals the shift from local, loosely correlated, prominently sensory-driven patterns to internally organized, spatially distributed, and temporally precise activity.

Synaptic glutamate release is potentiated by short metabolic failure whereas longer durations of energy depletion lead to a postsynaptic failure of synaptic transmission.