Detection of unbinding transitional states in the charybdotoxin first-order dissociation from a Kv-channel reveals that the bound neurotoxin wobbles, suggesting diverse intermediates and dissociation pathways in this protein–protein interaction.
A novel lncRNA (Ephemeron) is connected to known post-transcriptional and epigenetic regulators as part of an integrated machinery, which controls the timely exit from the naïve state of mouse embryonic stem cells.
Neurons differ in their impact on collective cortical activity, with sensitive neurons forming a stable topological core, implicated in cortical-state transitions, while peripheral insensitive neurons are more responsive to stimuli.
A computational model shows that natural selection can cause populations to evolve a distinctive population-level phenotype: the ability to transition between collective states in response to the environment.
Responses to anesthetics differ among individuals and fluctuate stochastically despite constant drug concentration, however, the amount of noise driving transitions between the responsive and the unresponsive state is conserved.