3,406 results found
    1. Developmental Biology
    2. Neuroscience

    Comprehensive transcriptome analysis of cochlear spiral ganglion neurons at multiple ages

    Chao Li et al.
    RNA-Seq analysis and in vivo validation via genetic approach uncover that Scrt2 and Celf4 are expressed in inner ear auditory neurons throughout development.
    1. Microbiology and Infectious Disease

    Homeostatic control of cell wall hydrolysis by the WalRK two-component signaling pathway in Bacillus subtilis

    Genevieve S Dobihal et al.
    Molecular genetic analyses define the first homeostatic control pathway that maintains cell wall remodeling activity during bacterial growth.
    1. Developmental Biology

    Lola regulates Drosophila adult midgut homeostasis via non-canonical hippo signaling

    Xue Hao et al.
    The transcription factor Lola is defined as a non-canonical Hippo signaling component essential for Drosophila midgut homeostasis via its interaction with Warts and suppression on Dref and SkpA expression levels.
    1. Human Biology and Medicine

    Ankyrin-G mediates targeting of both Na+ and KATP channels to the rat cardiac intercalated disc

    Hua-Qian Yang et al.
    The functional interaction of Na+ and KATP channels at the intercalated disk of cardiomyocytes depends on Ankyrin G and is clinically relevant since KATP channel mutations affect Na+ channel expression.
    1. Cancer Biology
    2. Human Biology and Medicine

    PCK1 and DHODH drive colorectal cancer liver metastatic colonization and hypoxic growth by promoting nucleotide synthesis

    Norihiro Yamaguchi et al.
    The gluconeogenic enzyme PCK1 and pyrimidine nucleotide biosynthetic enzyme DHODH drive hypoxic pyrimidine nucleotide biosynthesis and liver metastatic colonization in colorectal cancer, which is therapeutically exploitable by DHODH pharmacologic inhibition.
    1. Structural Biology and Molecular Biophysics

    Two forms of Opa1 cooperate to complete fusion of the mitochondrial inner-membrane

    Yifan Ge et al.
    An in vitro reconstitution assay reveals stoichiometric levels of the short form of Opa1 work together with the long form of Opa1 to mediate efficient and fast membrane pore opening.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Repressive H3K9me2 protects lifespan against the transgenerational burden of COMPASS activity in C. elegans

    Teresa Wei-sy Lee et al.
    The transgenerational inheritance of lifespan is facilitated by the accumulation of repressive chromatin across generations.
    1. Structural Biology and Molecular Biophysics

    Molecular basis of force-from-lipids gating in the mechanosensitive channel MscS

    Bharat Reddy et al.
    The structure of the mechanosensitive channel MscS embedded in a lipid bilayer redefines the nature, location and importance of lipid–protein interactions in the gating of mechanosensitive channels.
    1. Cell Biology
    2. Computational and Systems Biology

    A regulatory microRNA network controls endothelial cell phenotypic switch during sprouting angiogenesis

    Stefania Rosano et al.
    Coordinated microRNAs activity induced by VEGF represses cell proliferation and favors cell migration at the onset of sprouting angiogenesis in endothelial cells.
    1. Human Biology and Medicine
    2. Neuroscience

    Human hippocampal CA3 damage disrupts both recent and remote episodic memories

    Thomas D Miller et al.
    Human hippocampal cornu ammonis 3 damage impairs both recent and remote autobiographical episodic memory, and disrupts functional integration in medial temporal lobe subsystem regions of the default network.

Refine your results by:

Type
Research categories