Dimension reduction and machine learning tools were used to identify novel associations between the HIV reservoir and the immune systems of people with HIV.
James Alexander Briggs, Victor C Li ... Marc W Kirschner
Single cell RNA sequencing reveals that mouse embryonic stem cells can be differentiated into the same terminal motor neuron state via distinct differentiation paths, one of which includes a surprising intermediate state not found in embryos.
A comparison between artificially created allopolyploids and natural ones reveals that the latter underwent significant evolutionary steps after their formation.
Alexander Fengler, Lakshmi N Govindarajan ... Michael J Frank
A novel method and software provides researchers with the capability to rapidly, flexibly, and robustly perform Bayesian parameter estimation of theoretically meaningful models in cognitive neuroscience that were heretofore intractable.
Integrating multi-omics quantitative trait loci and genome-wide association study data into a multivariable Mendelian randomization framework allows to identify metabolite-mediated transcript-to-phenotype causal relations missed by methods focusing on a single omics layer.
Elena Bollati, Niclas H Lyndby ... Daniel Wangpraseurt
Scalar irradiance microsensor measurements performed inside the tissue of living corals show that absorption and fluorescence emission by host pigments produce dramatic spectral alterations in the light environment experienced by the symbionts.
Benjamin A Turturice, Juliana Theorell ... Patricia W Finn
Perinatal granulopoiesis and cord blood serum PGLYRP-1, a specific granule protein, are altered prior to onset of childhood asthma and provide potential targets for early identification of at-risk populations.
Nicholas M Grebe, Jean Paul Hirwa ... Stacy Rosenbaum
Mountain gorillas, who live in close-knit social groups with siblings and non-siblings of both sexes throughout their lives, show distinct behavioral biases towards maternal versus paternal kin.
Susan Martin, Jessica Tyrrell ... Hanieh Yaghootkar
Using genetics, it is possible to uncouple higher adiposity from its adverse metabolic effects and show that some obesity-associated conditions may benefit from treating the metabolic effects alone, whilst others may benefit more from weight loss.