1,699 results found
    1. Chromosomes and Gene Expression

    Ribosome recycling is not critical for translational coupling in Escherichia coli

    Kazuki Saito et al.
    Without ribosome recycling factor, ribosomes in Escherichia coli accumulate in 3'-UTRs and queue upstream of stop codons, but no effects were observed on the translational coupling of neighboring genes.
    1. Chromosomes and Gene Expression
    2. Stem Cells and Regenerative Medicine

    Decoupling the impact of microRNAs on translational repression versus RNA degradation in embryonic stem cells

    Jacob W Freimer et al.
    The deletion of Ddx6 results in the translational upregulation, but not transcript stabilization, of microRNA targets in embryonic stem cells while largely phenocopying the overall impact of global microRNA loss.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure of RNA polymerase bound to ribosomal 30S subunit

    Gabriel Demo et al.
    Cryo-EM structures of the 30S*RNAP complex visualize co-localization of the transcription and translation machineries and provide insights into the transcription-translation synchrony, which coordinates gene expression in bacteria.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Protein biogenesis machinery is a driver of replicative aging in yeast

    Georges E Janssens et al.
    A comprehensive mapping of the proteome and transcriptome during the complete replicative lifespan of budding yeast predicted an increased abundance of the protein biogenesis machinery is most causal for aging.
    1. Neuroscience

    Brain endothelial cell TRPA1 channels initiate neurovascular coupling

    Pratish Thakore et al.
    Activation of TRPA1 channels on cerebral capillary endothelial cells initiates a retrograde signal that propagates and dilates upstream arterioles.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    mRNA poly(A)-tail changes specified by deadenylation broadly reshape translation in Drosophila oocytes and early embryos

    Stephen W Eichhorn et al.
    Profiling of mRNA poly(A)-tail lengths and translational efficiencies provides new insights into posttranscriptional gene regulation in early Drosophila development.
    1. Developmental Biology
    2. Neuroscience

    Receptor-specific interactome as a hub for rapid cue-induced selective translation in axons

    Max Koppers et al.
    Multiple axonal guidance receptors control the local and selective translation of mRNAs by binding to ribosomes, specific mRNAs and RNA-binding proteins.
    1. Neuroscience

    Paranoia as a deficit in non-social belief updating

    Erin J Reed et al.
    Paranoia is underwritten by variation in prior beliefs about how the world will change and how to learn from those changes.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Translational control of one-carbon metabolism underpins ribosomal protein phenotypes in cell division and longevity

    Nairita Maitra et al.
    Extensive molecular profiling shows how loss of highly similar, paralogous ribosomal proteins lead to distinct phenotypic outputs, through translational control of specific mRNAs.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    A new experimental platform facilitates assessment of the transcriptional and chromatin landscapes of aging yeast

    David G Hendrickson et al.
    A new technology for obtaining aged yeast cells helps reveal a striking connection between aging, slow growth, and stress.

Refine your results by:

Type
Research categories