2,082 results found
    1. Structural Biology and Molecular Biophysics

    Crystal structure of dopamine receptor D4 bound to the subtype selective ligand, L745870

    Ye Zhou et al.
    The structure of receptor-ligand complex reveals the ligand binding selectivity among different dopamine receptor subtypes and also shows how this ligand class inhibits receptor activity.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    A microtranslatome coordinately regulates sodium and potassium currents in the human heart

    Catherine A Eichel et al.
    Association of mRNA in discrete, cotranslational complexes regulates currents controlling excitability in human cardiomyocytes.
    1. Microbiology and Infectious Disease

    Perinatal hormones favor CC17 group B Streptococcus intestinal translocation through M cells and hypervirulence in neonates

    Constantin Hays et al.
    Hormonal concentrations found in over 7-day-old neonates favor CC17 GBS invasiveness in a process linked to intestinal M cells maturation and mediated by the CC17 GBS surface protein Srr2.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Chromatinization of Escherichia coli with archaeal histones

    Maria Rojec et al.
    Escherichia coli is surprisingly tolerant to chromatinization by archaeal histones, suggesting that histones can become established as ubiquitous chromatin proteins without interfering critically with some key DNA-templated processes.
    1. Cell Biology

    Negative regulation of autophagy by UBA6-BIRC6–mediated ubiquitination of LC3

    Rui Jia, Juan S Bonifacino
    An ensemble of the ubiquitin-activating enzyme UBA6 and ubiquitin-conjugating enzyme/ubiquitin-ligase BIRC6 mediates ubiquitination of LC3, targeting the latter for proteasomal degradation and thus attenuating autophagic degradation of cellular substrates.
    1. Cell Biology

    Function of hTim8a in complex IV assembly in neuronal cells provides insight into pathomechanism underlying Mohr-Tranebjærg syndrome

    Yilin Kang et al.
    A neuronal specific function of the mitochondrial chaperone, hTim8a in Complex IV biology provides insight into the pathomechanisms underlying the mitochondrial disease, Mohr-Tranebjaerg syndrome.
    1. Cell Biology
    2. Developmental Biology

    Multiplex live single-cell transcriptional analysis demarcates cellular functional heterogeneity

    Ayhan Atmanli et al.
    A novel live-cell mRNA imaging technology identifies individual living cells based on their gene expression and enables the concurrent study of their physiology.
    1. Neuroscience

    Brain clusterin protein isoforms and mitochondrial localization

    Sarah K Herring et al.
    Identification and characterization of multiple brain clusterin isoforms, including a mitochondrial matrix-targeted isoform, provides foundation to potentially clarify the link between these proteins and the development of late-onset Alzheimer’s disease.

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