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    1. Biochemistry and Chemical Biology

    eIF1A residues implicated in cancer stabilize translation preinitiation complexes and favor suboptimal initiation sites in yeast

    Pilar Martin-Marcos et al.
    Substitutions in general translation initiation factor eIF1A found as recurring somatic mutations in uveal melanoma destabilize the closed conformation of the preinitiation complex at the start codon and increase discrimination against suboptimal initiation codons genome-wide.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    mRNA-programmed translation pauses in the targeting of E. coli membrane proteins

    Nir Fluman et al.
    Translation pauses occur in strategic positions to facilitate the production of properly folded membrane proteins in bacteria.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Aven recognition of RNA G-quadruplexes regulates translation of the mixed lineage leukemia protooncogenes

    Palaniraja Thandapani et al.
    Arginine methylation regulates mRNA translation of key protooncogenes via an RGG/RG motif-containing protein called Aven.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Protein translocation channel of mitochondrial inner membrane and matrix-exposed import motor communicate via two-domain coupling protein

    Rupa Banerjee et al.
    Two domains of the peripheral membrane protein Tim44 interact with two different sectors of a translocase to coordinate the translocation of proteins across the inner mitochondrial membrane.
    1. Microbiology and Infectious Disease

    Genome-wide regulatory dynamics of translation in the Plasmodium falciparum asexual blood stages

    Florence Caro et al.
    Ribosome profiling has bridged the knowledge gap between transcription and translation during malaria blood stage development and provided a comprehensive gene expression resource for this parasite.
    1. Biochemistry and Chemical Biology

    Translation of 5′ leaders is pervasive in genes resistant to eIF2 repression

    Dmitry E Andreev et al.
    Most of the mRNAs whose translation is resistant to the stress-induced repression of protein synthesis contain upstream open reading frames that are efficiently translated under normal conditions.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Dynamics of ribosomes and release factors during translation termination in E. coli

    Sarah Adio et al.
    Translation termination is a stochastic process that utilizes loosely coupled motions of its players to complete protein synthesis and release the newly synthesized nascent chain toward its cellular destination.
    1. Biochemistry and Chemical Biology
    2. Human Biology and Medicine

    Repression of ferritin light chain translation by human eIF3

    Mia C Pulos-Holmes et al.
    Human ferritin light chain (FTL) mRNA translation is regulated via its 5'-untranslated region (5'-UTR) by three mechanisms: RNA folding, iron response protein binding, and eukaryotic translation initiation factor eIF3 binding.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    TASEP modelling provides a parsimonious explanation for the ability of a single uORF to derepress translation during the integrated stress response

    Dmitry E Andreev et al.
    A model reveals how translation of an mRNA leader could provide resistance to global downregulation of translation.
    1. Chromosomes and Gene Expression

    The β-hairpin of 40S exit channel protein Rps5/uS7 promotes efficient and accurate translation initiation in vivo

    Jyothsna Visweswaraiah et al.
    A structural element of mRNA exit channel protein Rps5 performs a critical role in start codon recognition during translation initiation by stabilizing initiator tRNA binding to the pre-initiation complex.