1,075 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Single methyl groups can act as toggle switches to specify transmembrane Protein-protein interactions

    Li He et al.
    The placement of single methyl groups at certain positions in the sequence of small model transmembrane proteins consisting solely of leucines and isoleucines can modulate highly specific, productive interactions with the transmembrane domain of the erythropoietin receptor.
    1. Cell Biology

    dPob/EMC is essential for biosynthesis of rhodopsin and other multi-pass membrane proteins in Drosophila photoreceptors

    Takunori Satoh et al.
    A membrane protein complex in the endoplasmic reticulum is a key factor for the biogenesis of multi-pass transmembrane proteins, including Rh1, and its loss causes retinal degeneration.
    1. Neuroscience

    Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by Transmembrane O-methyltransferase (Tomt)

    Timothy Erickson et al.
    A zebrafish model for a particular form of human deafness (DFNB63) changes our view of this disease by revealing a defect in the localization of Transmembrane channel-like proteins that are essential for mechanotransduction in sensory cells.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Mechanistic insight into the conserved allosteric regulation of periplasmic proteolysis by the signaling molecule cyclic-di-GMP

    Debashree Chatterjee et al.
    Structure-function analyses reveal the mechanistic underpinnings of inside-out transmembrane signaling that controls periplasmic proteolysis, and thereby biofilm formation, in bacteria and may be relevant in the context of other signaling proteins with similar control elements.
    1. Cell Biology
    2. Developmental Biology

    LINKIN, a new transmembrane protein necessary for cell adhesion

    Mihoko Kato et al.
    LINKIN and three of its interactors-RUVBL1, RUVBL2, and α-tubulin-are required for cells to migrate together during organogenesis.
    1. Cell Biology

    Membrane fluidity is regulated by the C. elegans transmembrane protein FLD-1 and its human homologs TLCD1/2

    Mario Ruiz et al.
    Inhibition of C. elegans FLD-1 or Human TLCD1/2 prevents saturated fat lipotoxicity by allowing increased levels of membrane phospholipids that contain fluidizing long-chain polyunsaturated fatty acids.
    1. Structural Biology and Molecular Biophysics

    Pre-transition effects mediate forces of assembly between transmembrane proteins

    Shachi Katira et al.
    A general mechanism for how powerful forces of assembly and protein mobility can emerge from phase transitions is established.
    1. Structural Biology and Molecular Biophysics

    Subdued, a TMEM16 family Ca2+-activated Cl channel in Drosophila melanogaster with an unexpected role in host defense

    Xiu Ming Wong et al.
    A newly characterized calcium-activated chloride channel has been implicated in the immune system of Drosophila, shedding light on an enigmatic family of transmembrane proteins that are ubiquitous in nature.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structures of the scanning and engaged states of the mammalian SRP-ribosome complex

    Rebecca M Voorhees, Ramanujan S Hegde
    Structures of the signal recognition particle before and after it captures a transmembrane domain suggest how it chooses, engages, and shields its clients during membrane protein targeting to the endoplasmic reticulum.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Role of Tim17 in coupling the import motor to the translocation channel of the mitochondrial presequence translocase

    Keren Demishtein-Zohary et al.
    First two transmembrane segments of Tim17 are involved in interaction with the channel and the second two with the motor of the presequence translocase suggesting how proteins are handed over during their translocation into mitochondria.

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