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    1. Biochemistry and Chemical Biology

    Mechanisms of PDZ domain scaffold assembly illuminated by use of supported cell membrane sheets

    Simon Erlendsson et al.
    Investigations of binding of the scaffold protein PICK1 to transmembrane proteins in their native membrane environment demonstrate potent but slow dynamics and reveal distinct binding modes supporting different biological functions.
    1. Structural Biology and Molecular Biophysics

    Structure and activation mechanism of the BBSome membrane protein trafficking complex

    Sandeep K Singh et al.
    Two cryo-EM structures of the mammalian BBSome show how the BBSome is recruited to membranes and activated by the GTPase ARL6 prior to binding transmembrane proteins.
    1. Cell Biology

    Ubiquitin-dependent folding of the Wnt signaling coreceptor LRP6

    Elsa Perrody et al.
    A novel folding machinery assists transmembrane proteins from the cytosolic side of the endoplasmic reticulum.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    EMC1-dependent stabilization drives membrane penetration of a partially destabilized non-enveloped virus

    Parikshit Bagchi et al.
    Biochemical and cell-based analyses reveal how a non-enveloped virus exploits the chaperone activity of an ER transmembrane protein to penetrate the ER membrane required for successful virus infection.
    1. Cell Biology
    2. Neuroscience

    The unfolded protein response is required for dendrite morphogenesis

    Xing Wei et al.
    The unfolded protein response regulates neuronal dendrite morphogenesis by controlling the folding of a transmembrane leucine-rich repeat (LRR) protein.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Identification of PLXDC1 and PLXDC2 as the transmembrane receptors for the multifunctional factor PEDF

    Guo Cheng et al.
    Two membrane proteins that belong to a new type of cell-surface receptor mediate the transmembrane signaling for a secreted factor that has broad therapeutic value.
    1. Structural Biology and Molecular Biophysics

    Ion Channels: From ions to insulin

    Voula Kanelis
    Electron cryo-microscopy has revealed the three-dimensional structure of a potassium channel that has a central role in regulating the release of insulin from the pancreas.
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    1. Cell Biology

    Autophagy: COPII vesicles and the expansion of the phagophore

    Catherine Rabouille
    A new study has identified the proteins that adapt COPII vesicles to the needs of starving cells.
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