1,655 results found
    1. Cell Biology

    A MET-PTPRK kinase-phosphatase rheostat controls ZNRF3 and Wnt signaling

    Minseong Kim et al.
    HGF-MET signaling phosphorylates- and PTPRK dephosphorylates ZNRF3 to regulate ZNRF3 internalization, functioning as a rheostat for Wnt signaling.
    1. Cell Biology
    2. Developmental Biology

    Par3 cooperates with Sanpodo for the assembly of Notch clusters following asymmetric division of Drosophila sensory organ precursor cells

    Elise Houssin et al.
    Baz/Par3 and Sanpdo are required for clustering and activation of Notch receptors to allow intra-lineage private communication following asymmetric division of Drosophila epithelial cells.
    1. Cell Biology
    2. Neuroscience

    TRPM7 is critical for short-term synaptic depression by regulating synaptic vesicle endocytosis

    Zhong-Jiao Jiang et al.
    Electrophysiological and live-cell imaging analyses identify a presynaptic function of Ca2+ influx via transient receptor potential melastatin 7 (TRPM7) channels.
    1. Genetics and Genomics

    The transcription factor Xrp1 is required for PERK-mediated antioxidant gene induction in Drosophila

    Brian Brown et al.
    The transcription factor Xrp1 mediates a previously unrecognized branch of stress-response signaling, specifically as a downstream effector of eIF2alpha kinases.
    1. Cell Biology
    2. Neuroscience

    The LRRK2 G2019S mutation alters astrocyte-to-neuron communication via extracellular vesicles and induces neuron atrophy in a human iPSC-derived model of Parkinson’s disease

    Aurelie de Rus Jacquet et al.
    Extracellular vesicles are proposed as novel, non-cell-autonomous mediators of neuronal atrophy in Parkinson's disease.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Mutational analysis to explore long-range allosteric couplings involved in a pentameric channel receptor pre-activation and activation

    Solène N Lefebvre et al.
    A pentameric channel-receptor was studied by combining allosteric mutations, electrophysiology, fluorescent reporters and normal mode analysis, to dissect the long-range allosteric couplings specifically involved in its pre-activation and activation.
    1. Immunology and Inflammation

    Structural variability and concerted motions of the T cell receptor – CD3 complex

    Prithvi R Pandey et al.
    The orientation of the TCR extracellular domain is highly variable and coupled to characteristic structural changes throughout the TCR - CD3 complex.
    1. Cell Biology

    A PX-BAR protein Mvp1/SNX8 and a dynamin-like GTPase Vps1 drive endosomal recycling

    Sho W Suzuki et al.
    PX-BAR Mvp1 and dynamin-like GTPase Vps1 drive retromer-independent endosomal recycling.
    1. Cancer Biology
    2. Cell Biology

    Fine-tuned repression of Drp1-driven mitochondrial fission primes a ‘stem/progenitor-like state’ to support neoplastic transformation

    Brian Spurlock et al.
    A mitochondria-based 'priming' of stemness happens by fine-tuned repression of the level or activity of the master regulator of mitochondrial fission, Drp1, which supports carcinogen-induced transformation in a keratinocyte model.
    1. Cell Biology
    2. Plant Biology

    Crosstalk between the chloroplast protein import and SUMO systems revealed through genetic and molecular investigation in Arabidopsis

    Samuel James Watson et al.
    The small ubiquitin-like modifier system directly regulates components of the chloroplast protein import apparatus, that is, TOC proteins, to control chloroplast biogenesis and plant development.

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