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    1. Ecology
    2. Evolutionary Biology

    Novel pathogen introduction triggers rapid evolution in animal social movement strategies

    Pratik Rajan Gupte, Gregory F Albery ... Franz J Weissing
    The introduction of infectious pathogens to a simulated animal population leads to rapid evolutionary transitions in how individuals move in a social context, with distinct movement morphs evolved that make trade-offs between sociality and infection risk.
    1. Microbiology and Infectious Disease

    Role of cytoneme structures and extracellular vesicles in Trichomonas vaginalis parasite-parasite communication

    Nehuén Salas, Manuela Blasco Pedreros ... Natalia de Miguel
    Understanding communication mechanisms between unicellular parasites is crucial in the development of novel therapies, as they rely on diverse modes of communication (like extracellular vesicle release, cytoneme, and filopodia formation) to regulate their behavior and survival.
    1. Developmental Biology
    2. Microbiology and Infectious Disease

    Hypoxia-induced tracheal elasticity in vector beetle facilitates the loading of pinewood nematode

    Xuan Tang, Jiao Zhou ... Jianghua Sun
    An insect-transmissible plant pathogen, Bursaphelenchus xylophilus, uniquely excavates hypoxia to increase vector capacity via Muc91C-enhanced elasticity of tracheal tubes.
    1. Medicine

    Pharmacometrics of high-dose ivermectin in early COVID-19 from an open label, randomized, controlled adaptive platform trial (PLATCOV)

    William HK Schilling, Podjanee Jittamala ... Nicholas J White
    Pharmacometric evaluation of viral clearance rates based on frequent oropharyngeal sampling is a highly efficient and well-tolerated method of assessing and comparing SARS-CoV-2 antiviral therapeutics in vivo.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite

    Abhinay Ramaprasad, Paul-Christian Burda ... Michael J Blackman
    The malaria parasite uses an enzyme called GDPD to absorb choline, an important nutrient, from the bloodstream and this is essential for the parasite to survive inside the red blood cell.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    COVID-19 cluster size and transmission rates in schools from crowdsourced case reports

    Paul Tupper, Shraddha Pai ... Caroline Colijn
    Fitting a simple model of COVID-19 transmission to crowdsourced case report data allowed the estimation of mean cluster size and transmission rates in Canadian schools, as well as determining which interventions are most likely to limit transmission.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Effectiveness of rapid SARS-CoV-2 genome sequencing in supporting infection control for hospital-onset COVID-19 infection: Multicentre, prospective study

    Oliver Stirrup, James Blackstone ... Judith Breuer
    Sequencing of viral genomes could be useful for infection prevention and control within hospitals, but did not lead to a reduction in the rate of hospital-acquired SARS-CoV-2 infections over winter 2020/2021 in a large multicentre UK study.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A mosaic-type trimeric RBD-based COVID-19 vaccine candidate induces potent neutralization against Omicron and other SARS-CoV-2 variants

    Jing Zhang, Zi Bo Han ... Qi Ming Li
    Animal experiments show that the mosaic-type immunogen integrating key mutations from Omicron and other circulating variants elicits broad neutralization against divergent SARS-CoV-2 strains.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Regional importation and asymmetric within-country spread of SARS-CoV-2 variants of concern in the Netherlands

    Alvin X Han, Eva Kozanli ... Chantal Reusken
    Flight restrictions targeted at countries where SARS-CoV-2 variant-of-concern first emerged have limited effectiveness in deterring their introduction into the Netherlands due to the strength of regional travel importation risks in Europe.
    1. Epidemiology and Global Health

    COVID-19 pandemic dynamics in South Africa and epidemiological characteristics of three variants of concern (Beta, Delta, and Omicron)

    Wan Yang, Jeffrey L Shaman
    Model-inference reconstructed SARS-CoV-2 transmission dynamics in South Africa during March 2020 to February 2022, and quantified the immune erosion potential and transmissibility of three major variants (Beta, Delta, and Omicron), highlighting their common characteristics and the need for more proactive preparedness.