1,187 results found
    1. Structural Biology and Molecular Biophysics

    Characterisation of molecular motions in cryo-EM single-particle data by multi-body refinement in RELION

    Takanori Nakane et al.
    Multi-body refinement in RELION allows high-resolution reconstruction and visualisation of molecular motions in cryo-EM single-particle data sets with continuous forms of structural heterogeneity.
    1. Cell Biology
    2. Developmental Biology and Stem Cells

    A transcriptomics resource reveals a transcriptional transition during ordered sarcomere morphogenesis in flight muscle

    Maria L Spletter et al.
    A developmental transcriptomics resource from Drosophila flight muscles quantifies the transcriptional dynamics during muscle morphogenesis and identifies three ordered phases of sarcomere morphogenesis.
    1. Biochemistry and Chemical Biology

    Group II intron inhibits conjugative relaxase expression in bacteria by mRNA targeting

    Guosheng Qu et al.
    Group II introns can target mRNA, causing inhibition of gene expression, as a potential driver for evolution to the spliceosome.
    1. Neuroscience

    Functional limb muscle innervation prior to cholinergic transmitter specification during early metamorphosis in Xenopus

    Francois M Lambert et al.
    Molecular labeling, electrophysiology and calcium imaging have revealed a novel switching of neurotransmitter at the frog neuromuscular junction where motoneurons transiently release glutamate before acetylcholine at synapses on developing hindlimb muscles at the onset of metamorphosis.
    1. Neuroscience

    Social interaction-induced activation of RNA splicing in the amygdala of microbiome-deficient mice

    Roman M Stilling et al.
    Social-interaction impairment in germ-free mice is associated with a markedly altered transcriptional response to social novelty in the amygdala, as characterised by replacement of upregulation of common stimulus-induced pathways with upregulation of the splicing machinery.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    High-quality ultrastructural preservation using cryofixation for 3D electron microscopy of genetically labeled tissues

    Tin Ki Tsang et al.
    A broadly applicable method that faithfully preserves genetically labeled cellular structures for 3D electron microscopy (EM) and correlated light and electron microscopy (CLEM).
    1. Computational and Systems Biology
    2. Epidemiology and Global Health

    The intractable challenge of evaluating cattle vaccination as a control for bovine Tuberculosis

    Andrew James Kerr Conlan et al.
    Natural transmission experiments should be prioritised over risky and expensive field trials, in order to establish the impact of cattle vaccination on the transmission of bovine Tuberculosis.
    1. Neuroscience

    Downregulation of ribosome biogenesis during early forebrain development

    Kevin F Chau et al.
    Unbiased transcriptome analyses reveal that neural progenitor cells downregulate protein biosynthetic machinery during early forebrain development, and this fundamental process matches proteomic changes in the adjacent cerebrospinal fluid and is regulated in part by MYC.
    1. Neuroscience

    Energy exchanges at contact events guide sensorimotor integration

    Ali Farshchian et al.
    The brain obtains and preserves a consistent temporal alignment of multisensory and motor information flowing along staggered streams by maintaining an invariant estimate across modalities of the energy exchanged with the environment at discrete events.

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