A user-friendly genetically-encoded fluorescent sensor of improved dynamic range is introduced to facilitate the study of mitochondrial metabolism and diversity.

Automated liquid handling, whole mount staining, and clearing allow unbiased 3D quantitation of cell markers in human neural organoids with diameters of up to 1 mm at the single-cell level.

Multivesicular bodies deliver long-range retrograde nerve growth factor (NGF) signals and serve as essential signaling and sorting platforms in the cell soma, and multivesicular body (MVB) cargoes dictate their vesicular fate.

Using barcoded mutagenesis and a high-throughput genetic screen results in the identification of 150 genes that affect lipid accumulation in a non-model yeast system.

Pharmacometric evaluation of viral clearance rates based on frequent oropharyngeal sampling is a highly efficient and well-tolerated method of assessing and comparing SARS-CoV-2 antiviral therapeutics in vivo.

Inner-ear drug delivery experiments show that the fluids in the cochlea circulate due to the peristaltic action of motile auditory receptor cells.

An unbiased screen using various stresses reveals selective mRNA transport into P-bodies, in which mRNAs are either stored or decayed in a process that may promote chronological lifespan in yeast.

Fixed, intact animals of C. elegans can be physically expanded with high isotropy, to enable super-resolved imaging of general proteins and nucleic acids throughout the organism, on conventional microscopes.

Muscarinic acetylcholine receptor type A in adult Drosophila inhibits Kenyon cells, and is required for aversive olfactory learning and learning-associated synaptic depression between Kenyon cells and their output neurons.

Mitochondria reach stable positions in dendrites during a critical developmental period of high motility.