287 results found
    1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    Structure of the transporter associated with antigen processing trapped by herpes simplex virus

    Michael L Oldham et al.
    Herpes simplex virus evades the immune response by inhibiting the TAP transporter with a peptide inhibitor ICP47 that has an extensive interface at the peptide translocation cavity and locks the transporter in an inactive state.
    1. Immunology and Inflammation

    Variations in HLA-B cell surface expression, half-life and extracellular antigen receptivity

    Brogan Yarzabek et al.
    Lymphocytes and monocytes maintain their cell surface HLA-B via different mechanisms, which in turn differently influence cell-surface expression, half-life and peptide receptivity of HLA-B allotypes.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A single power stroke by ATP binding drives substrate translocation in a heterodimeric ABC transporter

    Erich Stefan et al.
    Single-turnover studies reveal quantitative insights into the inner mechanics and unfold hidden facets in the conformational coupling of ATP binding, hydrolysis, and substrate translocation by ABC transporters.
    1. Immunology and Inflammation

    RNF41 regulates the damage recognition receptor Clec9A and antigen cross-presentation in mouse dendritic cells

    Kirsteen M Tullett et al.
    Dendritic cell recognition and processing of antigens from dead cells, utilising the Clec9A-damage recognition receptor, is controlled by a novel RNF41-ubiquitin-mediated regulatory pathway.
    1. Immunology and Inflammation

    Endothelial heterogeneity across distinct vascular beds during homeostasis and inflammation

    Ankit Jambusaria et al.
    Vascular endothelial cells in the brain, heart and lung exhibit tissue-specific heterogeneity and plasticity, expressing genes that were traditionally thought to be only expressed by the surrounding parenchymal tissue cells.
    1. Cell Biology
    2. Immunology and Inflammation

    A two-hybrid antibody micropattern assay reveals specific in cis interactions of MHC I heavy chains at the cell surface

    Cindy Dirscherl et al.
    A generally applicable two-hybrid assay demonstrates that MHC class I heavy chains devoid of beta-2 microglobulin associate within and across allotypes, with implications for endocytosis and autoimmunity.
    1. Cancer Biology

    Use of signals of positive and negative selection to distinguish cancer genes and passenger genes

    László Bányai et al.
    In contrast with earlier conclusions, negative selection has a major role in cancer evolution.
    1. Evolutionary Biology

    Chloroplast acquisition without the gene transfer in kleptoplastic sea slugs, Plakobranchus ocellatus

    Taro Maeda et al.
    The newly opened genome of a kleptoplastic mollusk, Plakobranchus ocellatus, indicated that sequestered plastids retain their activity within the animal cell without horizontal algal gene transfer to the animal nucleus.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    An essential dual-function complex mediates erythrocyte invasion and channel-mediated nutrient uptake in malaria parasites

    Daisuke Ito et al.
    Gene knockdowns reveal that the conserved RhopH protein complex functions in both host cell invasion and channel-mediated nutrient uptake in malaria.
    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    The structures of secretory and dimeric immunoglobulin A

    Sonya Kumar Bharathkar et al.
    The structures of secretory and dimeric IgA reveal pseudosymmetric assemblies of two antibody monomers, in which possible positions of antigen-binding fragments and accessibility to receptor-binding sites are limited.

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