A new method maps functional and structural features of yeast genomes with unprecedented ease and throughput, which allows identification of protein domains at the genome scale.
A near-complete flux balance analysis model of a minimal cell demonstrates the high essentiality of its metabolic genes, agrees well with experimental essentiality data and suggests some further gene removals.
A Drosophila fertility gene is identified that acts as a linker between HP1a and local H3K4 demethylation during HP1a-mediated gene silencing that is required for ovary development and transposon silencing..
Transposition reactions that occur during DNA replication and involve the termini of adjacent transposons can induce genome expansion by re-replication of transposon-flanking sequences.
A broadly useful phenotypic profiling dataset was generated and used to identify a cofactor required for a polar cell wall synthase in Corynebacterium glutamicum that is conserved throughout the Actinobacteria.
Jumping of transposable elements provides DNA-binding sites for the MADS-box transcription factor PHERES1, allowing the regulation of imprinted genes and other key endosperm development genes.
Analysis of the global genetic requirements and gene expression changes in E. coli in the presence of a simple microbiome revealed pairwise and higher-order interactions, and underlying molecular mechanisms.
The tetrameric structure of a casposase bound to DNA and its biochemical properties show how a transposase could have evolved to perform CRISPR-Cas spacer acquisition.
A female fertility syndrome in Drosophila called gonadal dysgenesis is caused by the P-transposase actively mobilizing a very short P-element variant that has been named the Har-P.
