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    1. Structural Biology and Molecular Biophysics

    Cryo-electron tomographic investigation of native hippocampal glutamatergic synapses

    Aya Matsui, Cathy Spangler ... Eric Gouaux
    By harnessing antibody fragments conjugated to small gold nanoparticles together with high pressure freezing, FIB/SEM milling and cryo-electron tomography, AMPA receptors were identified from mouse brain tissue.
    1. Structural Biology and Molecular Biophysics

    The molecular infrastructure of glutamatergic synapses in the mammalian forebrain

    Julia Peukes, Charlie Lovatt ... René A Frank
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cancer Biology
    2. Neuroscience

    Tumor-infiltrating nerves functionally alter brain circuits and modulate behavior in a mouse model of head-and-neck cancer

    Jeffrey Barr, Austin Walz ... Paola D Vermeer
    Nerve tracing and behavioral studies in tumor-bearing mice together with transcriptional and functional analysis reveal cancer-induced central and peripheral neuronal alterations that influence behavior.
    1. Neuroscience

    Ca2+ channel and active zone protein abundance intersects with input-specific synapse organization to shape functional synaptic diversity

    Audrey T Medeiros, Scott J Gratz ... Kate M O'Connor-Giles
    In vivo analysis of endogenously tagged Ca2+ channel subunits reveals unexpected differences in subunit composition and synapse-specific relationships between channel abundance and synaptic strength.
    1. Neuroscience

    An applicable and efficient retrograde monosynaptic circuit mapping tool for larval zebrafish

    Tian-Lun Chen, Qiu-Sui Deng ... Xu-Fei Du
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Drosophila HCN mediates gustatory homeostasis by preserving sensillar transepithelial potential in sweet environments

    MinHyuk Lee, Se Hoon Park ... KyeongJin Kang
    A hyperpolarization-activated cation channel, counteracting membrane depolarization, delimits the excitability of receptor neurons subjected to naturally prolonged stimulation to preserve the function of neighboring receptor neurons in Drosophila gustation.
    1. Neuroscience

    Tonotopy is not preserved in a descending stage of auditory cortex

    Miaoqing Gu, Shanshan Liang ... Xiaowei Chen
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Cell Biology
    2. Neuroscience

    Presynaptic Rac1 in the hippocampus selectively regulates working memory

    Jaebin Kim, Edwin Bustamante ... Scott H Soderling
    Presynaptic Rac1 inhibition in the hippocampus impairs spatial working memory, potentially by modulating the synaptic cytoskeleton and kinase-mediated phosphorylation of key synaptic vesicle proteins.
    1. Neuroscience

    Sex-peptide targets distinct higher order processing neurons in the brain to induce the female post-mating response

    Mohanakarthik P Nallasivan, Deepanshu ND Singh ... Matthias Soller
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience

    Glutamate neurotransmission from leptin receptor cells is required for typical puberty and reproductive function in female mice

    Cristina Sáenz de Miera, Nicole Bellefontaine ... Carol F Elias
    Glutamate neurotransmission from hypothalamic ventral premammillary nucleus is indispensable for leptin action in pubertal development and typical reproduction.
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