29 results found
    1. Structural Biology and Molecular Biophysics

    Structures of two aptamers with differing ligand specificity reveal ruggedness in the functional landscape of RNA

    Andrew John Knappenberger et al.
    RNA aptamers that are closely related and share a common scaffold can readily adapt to recognize new ligands through changes in just a few nucleotides.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Single methyl groups can act as toggle switches to specify transmembrane Protein-protein interactions

    Li He et al.
    The placement of single methyl groups at certain positions in the sequence of small model transmembrane proteins consisting solely of leucines and isoleucines can modulate highly specific, productive interactions with the transmembrane domain of the erythropoietin receptor.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Gene activation by a CRISPR-assisted trans enhancer

    Xinhui Xu et al.
    Both exogenous and endogenous genes can be highly activated in cells by a new dCas9-based activator, CRISPR-assisted trans enhancer, that can be used to activate genes for biomedical applications.
    1. Biochemistry and Chemical Biology

    A bacterial riboswitch class for the thiamin precursor HMP-PP employs a terminator-embedded aptamer

    Ruben M Atilho et al.
    Many bacteria use a tiny riboswitch aptamer to sense the thiamin precursor HMP-PP to regulate the production of another thiamin precursor HET-P to efficiently biosynthesize this essential coenzyme.
    1. Chromosomes and Gene Expression
    2. Human Biology and Medicine

    Trisomy 21 consistently activates the interferon response

    Kelly D Sullivan et al.
    Hyperactive interferon signaling is a hallmark of trisomy 21 and may contribute to many of the comorbidities associated with Down syndrome.
    1. Cell Biology

    The influence of dynein processivity control, MAPs, and microtubule ends on directional movement of a localising mRNA

    Harish Chandra Soundararajan, Simon L Bullock
    In vitro reconstitution of mRNA motility reveals the basis of directionally biased motion by groups of motors, their response to potential obstacles, and the consequences of reaching microtubule ends.
    1. Biochemistry and Chemical Biology

    Random-sequence genetic oligomer pools display an innate potential for ligation and recombination

    Hannes Mutschler et al.
    Random sequence RNA pools display an innate capacity for ligation and recombination, enabling them to “bootstrap” themselves towards higher compositional, informational and structural complexity.
    1. Chromosomes and Gene Expression

    An mRNA-binding channel in the ES6S region of the translation 48S-PIC promotes RNA unwinding and scanning

    Irene Díaz-López et al.
    The ES6S region of the small subunit ribosome makes a place for the threading and secondary structure unwinding of mRNA, which regulates genome-wide translation.
    1. Biochemistry and Chemical Biology

    Rational design of aptazyme riboswitches for efficient control of gene expression in mammalian cells

    Guocai Zhong et al.
    An empirically derived scoring system for identifying optimal communication modules of aptazymes accelerates the development of ligand-responsive RNA genetic switches functional in mammalian cells.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    The target of the DEAH-box NTP triphosphatase Prp43 in Saccharomyces cerevisiae spliceosomes is the U2 snRNP-intron interaction

    Jean-Baptiste Fourmann et al.
    Prp43 binds to the pre-mRNA and contacts predominantly U2 proteins in the budding yeast spliceosome.

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