3,745 results found
    1. Developmental Biology
    2. Neuroscience

    Differential spatiotemporal development of Purkinje cell populations and cerebellum-dependent sensorimotor behaviors

    Gerrit Cornelis Beekhof et al.
    Different Purkinje cell subpopulations show distinct developmental profiles of physiological activity, climbing fiber inputs and axonal and dendritic morphology, matching different timelines of cerebellum-dependent behaviors.
    1. Epidemiology and Global Health

    High infectiousness immediately before COVID-19 symptom onset highlights the importance of continued contact tracing

    William S Hart et al.
    Fitting a mechanistic model to data from SARS-CoV-2 source-recipient pairs generates improved estimates of changes in infectiousness during infection, indicating substantial transmission shortly before symptom onset.
    1. Cell Biology

    An in vivo reporter for tracking lipid droplet dynamics in transparent zebrafish

    Dianne Lumaquin et al.
    A novel transgenic lipid droplet reporter in transparent casper zebrafish allows direct visualization of individual lipid droplets in a living animal.
    1. Cell Biology

    Micron-scale geometrical features of microtubules as regulators of microtubule organization

    Nandini Mani et al.
    Micron-scale geometrical features of individual microtubule polymers and polymer networks encode information that guides the self-organization of microtubules into specialized structures for diverse cellular functions such as cell division and signaling in eukaryotic cells.
    1. Epidemiology and Global Health

    Alpha-1 adrenergic receptor antagonists to prevent hyperinflammation and death from lower respiratory tract infection

    Allison Koenecke et al.
    Patients exposed to ⍺1-AR antagonists have reduced risks of mechanical ventilation and death in lower respiratory tract infection-related illnesses, highlighting the need for prospective trials assessing ⍺1-AR antagonists' effectiveness in COVID-19.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Detecting adaptive introgression in human evolution using convolutional neural networks

    Graham Gower et al.
    Convolutional neural networks are an effective tool for detecting archaic adaptive introgression from genomic data.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Asymmetric localization of the cell division machinery during Bacillus subtilis sporulation

    Kanika Khanna et al.
    During sporulation, FtsAZ filaments mediating cell division in Bacillus subtilis are positioned asymmetrically around the septum only on the mother cell side, making the septum thinner than during vegetative growth.
    1. Structural Biology and Molecular Biophysics

    Handling of intracellular K+ determines voltage dependence of plasmalemmal monoamine transporter function

    Shreyas Bhat et al.
    Subtle differences in handling of intracellular cations can drive macroscopic functional differences in structurally similar monoamine transporters.
    1. Neuroscience

    Presynaptic NMDA receptors facilitate short-term plasticity and BDNF release at hippocampal mossy fiber synapses

    Pablo J Lituma et al.
    By facilitating glutamate and BDNF release, presynaptic NMDA receptors may control information transfer from the dentate gyrus to the CA3 area of the hippocampus.
    1. Genetics and Genomics
    2. Medicine

    Tendon and motor phenotypes in the Crtap-/- mouse model of recessive osteogenesis imperfecta

    Matthew William Grol et al.
    Ultrastructural, biochemical, and behavioral assessments reveal that the Crtap-/- mouse model of severe, recessive Osteogenesis Imperfecta presents with defects in tendon structure and strength that correlate with severe motor deficits.

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