96 results found
    1. Neuroscience

    A virtual burrow assay for head–fixed mice measures habituation, discrimination, exploration and avoidance without training

    Andrew JP Fink et al.
    A naturalistic assay for head-fixed mice permits observation of a diverse set of innate and learned behaviors without requiring any training.
    1. Neuroscience

    Kv1.1 contributes to a rapid homeostatic plasticity of intrinsic excitability in CA1 pyramidal neurons in vivo

    Peter James Morgan et al.
    Short, theta-bursts of action potential firing decrease the global excitability of CA1 pyramidal neurons, providing an internal mechanism which could regulate their allocation to memory engrams.
    1. Physics of Living Systems

    Downsizing the molecular spring of the giant protein titin reveals that skeletal muscle titin determines passive stiffness and drives longitudinal hypertrophy

    Ambjorn Brynnel et al.
    Genetically altering the size of the molecular spring element in the giant protein titin established that titin determines the stiffness of skeletal muscle and the number of sarcomeres in series.
    1. Neuroscience

    Behavioral-state modulation of inhibition is context-dependent and cell type specific in mouse visual cortex

    Janelle MP Pakan et al.
    The three main types of inhibitory neurons in mouse primary visual cortex respond differently to locomotion in darkness and during visual stimulation, revealing context-dependent responses to changes in behavioral state.
    1. Neuroscience

    Spatial cell firing during virtual navigation of open arenas by head-restrained mice

    Guifen Chen et al.
    A mouse virtual reality system is presented which allows normal spatial behavior and place, grid and head-direction cell firing patterns in 2-D arenas, and is compatible with electrophysiology and multi-photon imaging.
    1. Neuroscience

    Bmal1 function in skeletal muscle regulates sleep

    J Christopher Ehlen et al.
    Expression of transcription factor BMAL1 in skeletal muscle reduces the recovery response to sleep loss and is both necessary and sufficient to regulate total sleep amount.
    1. Neuroscience

    Synaptic representation of locomotion in single cerebellar granule cells

    Kate Powell et al.
    The first patch-clamp recordings from single cerebellar granule cells during locomotion reveal that the entire step sequence can be predicted from both excitatory synaptic input and output spikes from a single neuron.
    1. Neuroscience

    A cortical disinhibitory circuit for enhancing adult plasticity

    Yu Fu et al.
    Building on previous work (Kaneko and Stryker, 2014), we report that the specific population of inhibitory neurons that increases the responses of neurons in the visual cortex during locomotion will also, when activated or blocked artificially, dramatically alter adult cortical plasticity, revealing that the aerobic exercise of locomotion is not necessary.
    1. Neuroscience

    Decision and navigation in mouse parietal cortex

    Michael Krumin et al.
    When mice use vision to choose their trajectories, a large fraction of parietal cortex activity can be precisely predicted from navigational attributes such as spatial position and heading.
    1. Neuroscience

    Asymmetric effects of activating and inactivating cortical interneurons

    Elizabeth AK Phillips, Andrea R Hasenstaub
    The consequences of manipulating neuronal activity with techniques such as optogenetics are highly sensitive to methodological details, highlighting the need for caution when interpreting results.

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