105 results found
    1. Neuroscience

    Spinal microcircuits comprising dI3 interneurons are necessary for motor functional recovery following spinal cord transection

    Tuan V Bui et al.
    A genetically-defined population of spinal interneurons is reciprocally connected with spinal locomotor circuits and mediates recovery of locomotor function following spinal cord transection.
    1. Stem Cells and Regenerative Medicine

    Loss of adult skeletal muscle stem cells drives age-related neuromuscular junction degeneration

    Wenxuan Liu et al.
    Building on previous work (Liu et al., 2015), it is shown that depletion or rescue of adult skeletal muscle stem cells is sufficient to induce or attenuate age-associated neuromuscular junction deterioration respectively.
    1. Neuroscience

    Inhibitory control of correlated intrinsic variability in cortical networks

    Carsen Stringer et al.
    A new cortical network model fit directly to multi-neuron recordings reveals that local inhibitory feedback can control neural dynamics, modulate brain state and enhance sensory processing.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Diverse fates of uracilated HIV-1 DNA during infection of myeloid lineage cells

    Erik C Hansen et al.
    Uracil/adenine base pairs in HIV-1 DNA are attacked by the uracil base excision repair machinery in macrophages, which leads to HIV restriction and viral genome diversification by transcription-associated mutagenesis.
    1. Neuroscience

    The recovery of standing and locomotion after spinal cord injury does not require task-specific training

    Jonathan Harnie et al.
    Restoring locomotion after complete spinal cord injury does not require locomotor training, only the return of sufficient excitability within neurons of the spinal cord.
    1. Cell Biology
    2. Neuroscience

    Transverse tubule remodeling enhances Orai1-dependent Ca2+ entry in skeletal muscle

    Antonio Michelucci et al.
    Structural and functional analyses show that transverse tubule association with stacks of sarcoplasmic reticulum enhances Orai1-dependent Ca2+ entry to replenish Ca2+ stores, maintain Ca2+ release, and maximize force during exercise.
    1. Neuroscience

    Anatomical basis and physiological role of cerebrospinal fluid transport through the murine cribriform plate

    Jordan N Norwood et al.
    Chemical ablation of olfactory sensory neurons blocks cerebrospinal fluid outflow into the nasal epithelium, leading to alterations of cerebrospinal fluid dynamics.
    1. Neuroscience

    Visual cue-related activity of cells in the medial entorhinal cortex during navigation in virtual reality

    Amina A Kinkhabwala et al.
    Cue cells in the medial entorhinal cortex encode visual cues during virtual navigation, supporting the hypothesis that the brain represents visual cue information to error-correct grid cell firing during path-integration.
    1. Neuroscience

    A dystonia-like movement disorder with brain and spinal neuronal defects is caused by mutation of the mouse laminin β1 subunit, Lamb1

    Yi Bessie Liu et al.
    A mouse with a defined mutation in an extracellular matrix protein that is expressed in selected neurons sheds light on circuit abnormalities producing transient hyperkinetic movements.
    1. Cell Biology

    Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness

    Arpit Sharma et al.
    Skeletal muscle mitochondrial pyruvate carrier disruption increases muscle fatty acid oxidation and systemic glucose turnover that drive whole-body leanness.

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