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Nuclei and spatial system dimensions control local concentrations of cell cycle regulators, determining the spatial origin of waves that coordinate​ DNA replication and, subsequently, cell division.

Discovery of a novel neuropeptide signalling system in a deuterostome invertebrate reveals the evolutionary origin of prolactin-releasing peptide and its relationship with neuropeptides in protostome invertebrates.

Sequential introduction of transcription factors enables large-scale generation of induced motor neurons (iMNs) from human somatic cells, and transplantation of iMNs exhibit therapeutic effects in spinal cord injury model.

The amino terminus of acid-sensing ion channel 1a forms a reentrant 'loop' that frames the lower pore and harbors a conserved 'His-Gly' motif implicated in gating and ion selectivity mechanisms.

A SWI/SNF-family chromatin remodeling subcomplex from yeast is identified (RSC1) that is specialized to slide nucleosomes residing on DNA sequences that confer partial nucleosome unwrapping, with assistance from accessory factors.

Dorsal raphe Pet1 neurons are molecularly heterogeneous, comprising as many as fourteen distinct subtypes that show biased cell body distributions across dorsal raphe subdomains.

Multiple steps of the atypical cell cycles underlying Plasmodium gametogony are controlled by a divergent cyclin/cyclin-dependent complex.

Identification of a two-tier functional redundancy to combat proteostasis imbalance induced due to tRNA expansion and oxidative stress in multicellular animals.

By thinking about experimental techniques in terms of six broad approaches – perturbation, visualization, substitution, characterization, reconstitution, and simulation – researchers may be able to generate more reliable inferences.

Conformational flexibility in HIV-1 capsid, provided by cyclophilin A binding, facilitates evasion of capsid-targeting restriction factor MxB, while allowing sequence change to facilitate cytotoxic T-cell evasion.