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Human Biology and Medicine
Non-invasive imaging of CSF-mediated brain clearance pathways via assessment of perivascular fluid movement with diffusion tensor MRI
Ian F Harrison et al.
The first non-invasive technique to assess the action of brain clearance mechanisms, driven by the perivascular inflow of cerebrospinal fluid, has been developed using magnetic resonance imaging.
Actin assembly ruptures the nuclear envelope by prying the lamina away from nuclear pores and nuclear membranes in starfish oocytes
Natalia Wesolowska et al.
Combined light and electron microscopy reveals a new function for Arp2/3-mediated actin assembly in nuclear envelope rupture, which leads to a separation of nuclear membranes and pores from the lamina.
Stem Cells and Regenerative Medicine
The retromer complex safeguards against neural progenitor-derived tumorigenesis by regulating Notch receptor trafficking
Bo Li et al.
The retromer complex serves as a bomb squad to retrieve and disarm the potentially harmful pool of Notch receptors in a timely manner and thereby safeguards against brain tumor formation.
Epidemiology and Global Health
Microbiology and Infectious Disease
Two complement receptor one alleles have opposing associations with cerebral malaria and interact with α
D Herbert Opi et al.
Analysis of a large Kenyan dataset may resolve previously conflicting studies by identifying polymorphisms which interact to modify the risk of cerebral malaria.
Cell-type heterogeneity in the early zebrafish olfactory epithelium is generated from progenitors within preplacodal ectoderm
Raphaël Aguillon et al.
Several neuronal subtypes found in the early zebrafish olfactory placode are not derived from the neural crest, as previously thought, but from the preplacodal ectoderm.
Sleep deprivation suppresses aggression in
Matthew S Kayser et al.
A single night of sleep deprivation suppresses fighting behaviors in male fruit flies, with consequent impairments in reproductive fitness.
Biochemistry and Chemical Biology
Structural Biology and Molecular Biophysics
RNA-guided assembly of Rev-RRE nuclear export complexes
Yun Bai et al.
Tertiary folding of the Rev-response element (RRE) in HIV RNA ensures the rapid formation of the Rev-RRE viral ribonucleoprotein particle via a two-step process.
Curvature-induced expulsion of actomyosin bundles during cytokinetic ring contraction
Junqi Huang et al.
Cytokinetic actomyosin ring disassembly occurs through a novel mechanism in which the increased ring curvature, generated through contraction, itself promotes the disassembly process.
Live imaging of heart tube development in mouse reveals alternating phases of cardiac differentiation and morphogenesis
Kenzo Ivanovitch et al.
Tissue-level coordination of cardiac progenitor cells in the early mouse embryo produces a temporal compartmentalization of differentiation and morphogenesis essential for heart tube formation.
Physics of Living Systems
Interplay of cell dynamics and epithelial tension during morphogenesis of the
Raphaël Etournay et al.
Autonomous patterns of cell contraction in the context of localized apical extracellular matrix constraints specify tissue stresses that reshape the wing epithelium.
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