1,857 results found
    1. Ecology

    The effect of host community functional traits on plant disease risk varies along an elevational gradient

    Fletcher W Halliday et al.
    Environmental gradients can modify a fundamental relationship between host community structure and disease, with implications for predicting disease risk in a changing world.
    1. Medicine

    The hepcidin regulator erythroferrone is a new member of the erythropoiesis-iron-bone circuitry

    Melanie Castro-Mollo et al.
    The hepcidin regulator erythroferrone functions by sequestering BMPs and is an important modulator of bone remodeling, providing new mechanistic insight into how premature osteoporosis persists in optimally transfused β-thalassemic patients.
    1. Epidemiology and Global Health

    Convalescent plasma use in the USA was inversely correlated with COVID-19 mortality

    Arturo Casadevall et al.
    A population-level analysis of convalescent plasma use and COVID-19 mortality in the USA revealed an inverse correlation and an estimate that recent declines in plasma use could have resulted in about 30,000 excess deaths.
    1. Ecology
    2. Plant Biology

    Genetic variation, environment and demography intersect to shape Arabidopsis defense metabolite variation across Europe

    Ella Katz et al.
    Measurements of specialized metabolites across a population of 800 natural Arabidopsis thaliana accessions revealed different pressures and evolutionary processes that shaped their variation and distribution across Europe.
    1. Evolutionary Biology

    Myoglobin primary structure reveals multiple convergent transitions to semi-aquatic life in the world's smallest mammalian divers

    Kai He et al.
    Ancestral sequence reconstruction of an essential muscle protein involved in O2 storage and transport accurately tracks secondary aquatic transitions in a speciose clade of insectivorous mammals.
    1. Biochemistry and Chemical Biology

    Dwarf open reading frame (DWORF) is a direct activator of the sarcoplasmic reticulum calcium pump SERCA

    M'Lynn E Fisher et al.
    Activation of the sarcoplasmic reticulum calcium pump and enhancement of cellular calcium homeostasis by dwarf open reading frame reveal how this small membrane protein opposes phospholamban inhibitory function in cardiac muscle.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Repression by the Arabidopsis TOPLESS corepressor requires association with the core mediator complex

    Alexander R Leydon et al.
    The TPL corepressor binds to the core mediator complex through MED21 to inhibit transcription while simultaneously priming repressed genes for rapid reactivation.
    1. Developmental Biology
    2. Neuroscience

    Differential spatiotemporal development of Purkinje cell populations and cerebellum-dependent sensorimotor behaviors

    Gerrit Cornelis Beekhof et al.
    Different Purkinje cell subpopulations show distinct developmental profiles of physiological activity, climbing fiber inputs and axonal and dendritic morphology, matching different timelines of cerebellum-dependent behaviors.

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