41 results found
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Competition between Tropomyosin, Fimbrin, and ADF/Cofilin drives their sorting to distinct actin filament networks

    Jenna R Christensen et al.
    Both cooperative and competitive associations of actin binding proteins with actin filaments help drive the self-organization of functionally diverse F-actin networks in fission yeast.
    1. Cell Biology

    Cooperation between tropomyosin and α-actinin inhibits fimbrin association with actin filament networks in fission yeast

    Jenna R Christensen et al.
    The contractile ring actin binding proteins tropomyosin Cdc8 and a-actinin Ain1 synergize to effectively compete with the endocytic actin patch protein fimbrin Fim1 for associating with F-actin networks.
    1. Neuroscience

    Chronic lithium treatment elicits its antimanic effects via BDNF-TrkB dependent synaptic downscaling

    Erinn S Gideons et al.
    The antimanic action of lithium requires BDNF-TrkB signaling coupled with enhanced dynamin-dependent endocytosis of AMPARs as a potential mechanism underlying the therapeutic effects.
    1. Developmental Biology

    Calcium handling precedes cardiac differentiation to initiate the first heartbeat

    Richard CV Tyser et al.
    High-resolution live imaging reveals how and when the mouse heart first starts to beat during development and how the onset of beating impacts on heart muscle cell maturation and heart formation.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Cofilin-induced unidirectional cooperative conformational changes in actin filaments revealed by high-speed atomic force microscopy

    Kien Xuan Ngo et al.
    A cluster of cofilin along an otherwise bare actin filament induces distinctively asymmetric cooperative conformational changes to the filament on either side of the cluster.
    1. Neuroscience

    Early structural and functional plasticity alterations in a susceptibility period of DYT1 dystonia mouse striatum

    Marta Maltese et al.
    Structural and functional striatal synaptic plasticity abnormalities occur early in a sensitive developmental period, representing a potential unique endophenotypic traits that increase the risk of manifesting clinical symptoms in DYT1 mutation carriers.
    1. Cell Biology

    Curvature-induced expulsion of actomyosin bundles during cytokinetic ring contraction

    Junqi Huang et al.
    Cytokinetic actomyosin ring disassembly occurs through a novel mechanism in which the increased ring curvature, generated through contraction, itself promotes the disassembly process.
    1. Cell Biology
    2. Computational and Systems Biology

    Transcriptional profiling reveals extraordinary diversity among skeletal muscle tissues

    Erin E Terry et al.
    There is no such thing as a representative skeletal muscle tissue, as each member of this family of tissues expresses a specialized mRNA program.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Small molecule-mediated refolding and activation of myosin motor function

    Michael B Radke et al.
    The small molecule EMD 57033 is one of a new class of pharmacological chaperones that stabilize, enhance the activity of, and correct stress-induced misfolding of myosin proteins.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Large-scale remodeling of a repressed exon ribonucleoprotein to an exon definition complex active for splicing

    Somsakul Pop Wongpalee et al.
    A protein regulator of alternative pre-mRNA splicing arrests spliceosome assembly at a previously unrecognized step that defines new intermediate stages in the formation of exon complexes.

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