A novel statistical framework and approach using sibling phenotype pairs allows inference of genetic architecture in the tails of complex traits to be made without genetic data.

Neuronal activity modulates blood–brain barrier permeability, influencing synaptic plasticity and local network reorganization in the healthy brain.

The spatial dimension of neural activity is an organizing feature of the neural code that controls motor actions.

Erythroid maturation-dependent remodelling of CTLH E3 complex, along with its cognate E2, controls the orderly progression of human erythropoiesis, thus establishing a paradigm for other E2-E3 ubiquitylation modules involved in developmental processes.

The repair of oxidatively damaged proteins by the newly discovered activity in YjbI is important for the adaptation of Bacillus subtilis to oxidative environments.

Elevated growth differentiation factor-15 (GDF15) levels do not appear to be a causal factor in body mass index (BMI) in humans but higher BMI does cause increases in GDF15.

Eutherian CD4 evolved counterbalancing motifs in the extracellular, transmembrane, and intracellular domains that regulate CD4⁺ T cell responses to peptide antigens presented by class II MHC (pMHCII).

Androglobin, a newly identified mammalian globin with a unique modular structure including a protease and calmodulin binding IQ domain within a circularly permuted globin domain, is implicated in murine spermatogenesis.

A MRI study of virally infected CNS demonstrates the utility of MRI in detecting the earliest pathological events and studying pathogen-specific T cells at the level of single cell as well as the therapeutic potential of antiviral T cells.