206 results found
    1. Cell Biology

    Cell membrane glycan contents are biochemical factors that constitute a kinetic barrier to viral particle uptake in a protein-nonspecific manner

    Yoshihisa Kaizuka, Rika Machida
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Solid
    1. Cell Biology

    Oxidized low-density lipoprotein potentiates angiotensin II-induced Gq activation through the AT1-LOX1 receptor complex: Implications for renal dysfunction

    Jittoku Ihara, Yibin Huang ... Koichi Yamamoto
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    1. Developmental Biology

    Partial rejuvenation of the spermatogonial stem cell niche after gender-affirming hormone therapy in trans women

    Emily Delgouffe, Samuel Madureira Silva ... Ellen Goossens
    Gender-affirming hormone therapy in trans women leads to a loss of mature characteristics in the spermatogonial stem cell niche, causes spermatogenic arrest, and triggers fibrotic processes.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Drosophila Hamlet mediates epithelial tissue assembly of the reproductive system

    Huazhen Wang, Ludivine Bertonnier-Brouty ... Qi Dai
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    • Convincing
    1. Developmental Biology

    CCDC113 stabilizes sperm axoneme and head-tail coupling apparatus to ensure male fertility

    Bingbing Wu, Chenghong Long ... Chao Liu
    CCDC113 is a key structural hub for sperm axoneme and head-tail coupling apparatus (HTCA) stability, with defects leading to male infertility through disruption of sperm flagellar and HTCA integrity.
    1. Developmental Biology

    Molecular, cellular, and developmental organization of the mouse vomeronasal organ at single cell resolution

    Max Henry Hills, Limei Ma ... C Ron Yu
    A transcriptomic atlas of the mouse vomeronasal organ reveals novel receptor co-expression patterns and provides a framework for understanding sensory neuron lineage and receptor specification.
    1. Developmental Biology
    2. Evolutionary Biology

    Single Cell Sequencing Provides Clues about the Developmental Genetic Basis of Evolutionary Adaptations in Syngnathid Fishes

    Hope M Healey, Hayden B Penn ... William A Cresko
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Cell Biology

    Spatiotemporal recruitment of the ubiquitin-specific protease USP8 directs endosome maturation

    Yue Miao, Yongtao Du ... Mei Ding
    The USP-50/USP8 protease removes the Rab5 GEF Rabex5 from endosomes while facilitating recruitment of the Rab7 GEF SAND-1/Mon1, promoting endosome maturation.
    1. Medicine
    2. Immunology and Inflammation

    Inhibition on neutrophil extracellular traps by oligomeric procyanidins alleviate chemotherapy-induced chronic kidney injury via gut-kidney axis

    Yaqi Luan, Weiwei He ... Rong Wang
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Cell Biology

    Nuclear translocation of SIRT4 mediates deacetylation of U2AF2 to modulate renal fibrosis through alternative splicing-mediated upregulation of CCN2

    Guangyan Yang, Jiaqing Xiang ... Shu Yang
    SIRT4 regulates cellular communication network factor 2 expression through U2 small nuclear RNA auxiliary factor 2-mediated pre-mRNA splicing, presenting a potential therapeutic target for kidney fibrosis.
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