AJ Venkatakrishnan, Arjun Puranik ... Venky Soundararajan
SARS-CoV-2 receptor ACE2 is expressed in nasal olfactory epithelia, tongue keratinocytes and small intestine enterocytes, connected with the COVID-19 patient phenotypes such as anosmia and diarrhea.
Cells in the tracheal systems of fruit fly larvae are organised into compartments with precisely located boundaries, which pattern the formation of branched tubular networks.
The Drosophila tracheal fate is stabilized by the combination of transcriptional programs to control tissue architecture and tissue-level input sensitive to tubular geometry, ensuring the robust mechanism of organ determination.
An insect-transmissible plant pathogen, Bursaphelenchus xylophilus, uniquely excavates hypoxia to increase vector capacity via Muc91C-enhanced elasticity of tracheal tubes.
Left-right asymmetric rotation of the Drosophila hindgut is driven by "cell sliding," a novel cellular behavior induced by chiral cell deformation, in which cells change their position relative to subjacent neighbors as sliding directionally.
A novel role of endosomal machineries retromer and ESCRT in membrane delivery of Drosophila septate junction components is required for maintenance of junction integrity and epithelial barrier function.
MakA, a pore-forming cytotoxin produced by Vibrio cholerae, forms oligomers and remodels membranes into high-curvature tubes, resulting in membrane integrity loss inside acidified organelle lumens or when cultured with cells in an acidic medium.
